New insights into spexin and pituitary adenylate cyclase-activating polypeptide (PACAP) in regulating fish reproduction

Abstract

Reproduction is one of the most crucial physiological processes for the continuation of the generation of any species. Teleost are one of the most divergent aquatic species. The reproductive neuro-endocrine regulatory studies are limited to only few species. Neuroendocrine regulation is a finely tuned complex mechanistic pathways, involving mainly hypothalamic-pituitary-gonad (HPG) axis. Within the HPG axis, gonadotropin-releasing hormone (GnRH) modulates the synthesis and release of pituitary gonadotropins, which act on the gonads to stimulate steroidogenesis and gametogenesis. Very recently, several novel neuropeptides, associated with reproductive regulation, have been identified. Spexin (SPX), a novel neuropeptide coevolved with the galanin/kisspeptin family, has been identified as a regulator of the species-specific reproductive processes in teleost. Pituitary adenylate cyclase-activating polypeptide (PACAP) is another novel member of the secretin-glucagon peptide family that functions as a hypophysiotropic factor involved in regulating pituitary hormone secretion in fish. These two emerging neuropeptides have pleiotropic functions, but information regarding their exact roles in fish reproduction is very limited. An updated overview of the mechanistic reproductive functions of these two new neuropeptides are highlighted in this review.