Dasatinib-Induced Transverse Melanonychia

IF 1.4 Q3 DERMATOLOGY
Mehul Tyagi, Vishal Gaurav, Japnoor Kaur
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Abstract

Introduction: Transverse melanonychia, characterized by grey to black pigmented bands traversing the nail plate, can occur as a side-effect of certain medications. While no documented reports specifically associate dasatinib, a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia, with nail changes, we present a case of transverse melanonychia possibly related to dasatinib therapy. Case Report: A 54-year-old male with CML, receiving dasatinib for 1.5 years, presented with transverse pigmented lines involving all fingernails and toenails. Clinical examination revealed discrete bands of transverse melanonychia in the nails. Onychoscopy of all finger- and toenails revealed multiple longitudinal grey lines within transverse grey bands of homogeneous chromonychia. Based on clinical presentation, onychoscopic features, and temporal association with dasatinib therapy, a provisional diagnosis of dasatinib-induced transverse melanonychia was made. Discussion: The exact mechanisms underlying melanonychia are not fully understood but may involve nail matrix or toxicity, stimulation of nail-matrix melanocytes, or drug deposition within the nail plate. This case highlights the possibility of dasatinib-induced transverse melanonychia and underscores the importance of monitoring and evaluating nail changes in patients undergoing dasatinib treatment.
达沙替尼诱导的横向黑色素瘤
& lt; b> & lt; i>简介:& lt; / i> & lt; / b>横向黑甲癣,特征是灰色到黑色的色素带穿过甲板,可能是某些药物的副作用。达沙替尼是一种酪氨酸激酶抑制剂,用于治疗慢性髓性白血病(CML)和急性淋巴细胞白血病,虽然没有文献报道专门将达沙替尼与指甲变化联系起来,但我们提出了一例可能与达沙替尼治疗有关的横向黑甲癣。& lt; b> & lt; i>案例报告:& lt; / i> & lt; / b>54岁男性CML患者,接受达沙替尼治疗1.5年,表现为指甲和脚趾甲出现横贯色素纹。临床检查发现甲内呈离散带状横切性黑甲。所有手指和脚趾甲的耳甲镜检查显示在均匀色甲的横向灰带中有多条纵向灰线。根据临床表现、甲镜特征和与达沙替尼治疗的时间相关性,初步诊断为达沙替尼诱导的横向黑甲癣。& lt; b> & lt; i>讨论:& lt; / i> & lt; / b>黑甲癣的确切机制尚不完全清楚,但可能与甲基质或毒性、甲基质黑素细胞的刺激或甲板内药物沉积有关。该病例强调了达沙替尼诱导横向黑甲的可能性,并强调了监测和评估接受达沙替尼治疗的患者指甲变化的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
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