CURRENT VIEWS ON THE ROLE OF GROWTH DIFFERENTIATION FACTOR 15 IN THE GENESIS, COURSE AND OUTCOME OF CARDIOVASCULAR PATHOLOGY

Abstract

Highlights The article summarizes the data on the influence of growth and differentiation factor 15 on the genesis, course and outcomes of cardiovascular system pathologies. The presented analysis of experts' opinions allows to approach the answer to the question, which is topical in the scientific community: whether this factor promotes the progression of cardiovascular diseases or performs a protective function. Abstract Growth and differentiation factor 15 (GDF-15) is a circulating protein and is associated with a variety of pathological processes, including being a marker of endothelial dysfunction. GDF-15 expression is upregulated in cardiomyocytes after ischemia, reperfusion, pressure overload and mechanical stretch, allowing it to be used for the diagnosis of subclinical coronary atherosclerosis, arterial hypertension and heart failure. This paper presents a review of studies that have focused on the diagnostic spectrum of this marker. We also considered two perspectives on the role of GDF-15 in the pathogenesis of cardiovascular disease: as a factor contributing to pathology progression or as performing a compensatory function? The introduction of highly specific markers, in particular GDF-15, into clinical practice may help to reduce the risk of cardiovascular complications, disability and mortality.