Epidemiological changes in invasive Streptococcus pyogenes infection during the UK alert period: A molecular comparative analysis from a tertiary Spanish hospital in 2023

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-01-01 DOI:10.1016/j.eimc.2023.09.004

Alfredo Maldonado-Barrueco , Iván Bloise , Emilio Cendejas-Bueno , Francisco López-Rodrigo , Julio García-Rodríguez , Fernando Lázaro-Perona

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引用次数: 0

Abstract

Objectives

To study the genomic epidemiology of Streptococcus pyogenes causing bloodstream infections (GAS-BSI) in a Spanish tertiary hospital during the United Kingdom invasive S. pyogenes outbreak alert.

Methods

Retrospective epidemiological analysis of GAS-BSI during the January–May 2017–2023 period. WGS was performed using Ion torrent GeneStudio™ S5 system for emm typing and identification of superantigen genes in S. pyogenes isolated during the 2022–2023 UK outbreak alert.

Results

During 2023, there were more cases of GAS-BSI compared to the same period of previous year with a non-significant increase in children. Fourteen isolates were sequenced. The emm1 (6/14, 42.9%) and emm12 (2/14, 14.3%) types predominated; 5 of 6 (75%) emm1 isolates were from the M1_UK clone. The most detected superantigen genes were speG (12/14, 85.7%), speC (10/14, 71.4%), speJ (7/14, 50%), and speA (5/15, 33.3%). speA and speJ were predominant in M1_UK clone.

Conclusions

Our genomic epidemiology in 2023 is similar to the reported data from the UK outbreak alert in the same period and different from previous national S. pyogenes surveillance reports.

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英国预警期间侵袭性化脓性链球菌感染的流行病学变化：2023 年西班牙一家三级医院的分子对比分析

目的研究英国入侵性化脓性链球菌疫情警报期间西班牙一家三级医院中引起血流感染（GAS-BSI）的化脓性链球菌的基因组流行病学。方法对 2017-2023 年 1-5 月期间的 GAS-BSI 进行回顾性流行病学分析。使用 Ion torrent GeneStudio™ S5 系统对 2022-2023 年英国疫情警报期间分离的化脓性链球菌进行了 WGS 测序，以进行 emm 分型和超抗原基因鉴定。结果2023 年期间，GAS-BSI 病例与上年同期相比有所增加，儿童病例增加不明显。对 14 个分离株进行了测序。其中以 emm1（6/14，42.9%）和 emm12（2/14，14.3%）型为主；6 个 emm1 分离物中有 5 个（75%）来自 M1UK 克隆。检测到最多的超抗原基因是 speG（12/14，85.7%）、speC（10/14，71.4%）、speJ（7/14，50%）和 speA（5/15，33.3%）。结论我们在 2023 年的基因组流行病学与同期英国疫情警报的报告数据相似，但与之前的全国化脓性链球菌监测报告不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.