Dachen Tian, Xin Hui, Lijun Zhang, Ji Liu, Mengen Wang, Tongtong Zhang, Xianjun Wang
{"title":"Migraine and Risk of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis","authors":"Dachen Tian, Xin Hui, Lijun Zhang, Ji Liu, Mengen Wang, Tongtong Zhang, Xianjun Wang","doi":"10.1155/2023/8887282","DOIUrl":null,"url":null,"abstract":"<div>\n <p><i>Background</i>. Migraine is a frequently observed neurological disease in patients with systemic lupus erythematosus. However, the relationship between these two conditions is still a subject of controversy. <i>Objectives</i>. Our aim was to investigate the association between migraine and the risk of developing systemic lupus erythematosus through a meta-analysis of case-control studies. <i>Methods</i>. Following the Preferred Reporting Project for Systematic Reviews and Meta-Analysis statement, we conducted a comprehensive search of the following literature databases, including PubMed, Embase, and Web of Science, to identify relevant articles published up to June 2022 using the keywords “migraine” and “systemic lupus erythematosus” as subject headings. If heterogeneity was expected to be low (<i>I</i><sup>2</sup> ≤ 50%), the pooled analysis was performed using a fixed-effects model calculated by the Mantel-Haenszel method. Analysis in this study was conducted using R software (http://www.r-project.org). <i>Results</i>. Six case-control experimental studies involving 908 participants were included in the meta-analysis. The overall combined relative risk of developing systemic lupus erythematosus in patients with migraine, compared to the control group, was 1.69 (95% confidence interval (CI): 1.26 to 2.27). The analysis revealed minimal evidence of heterogeneity and publication bias. <i>Conclusions</i>. Based on our meta-analysis, there is suggestive evidence that patients with migraine may have an elevated risk of developing systemic lupus erythematosus attacks.</p>\n </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2023 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2023/8887282","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2023/8887282","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background. Migraine is a frequently observed neurological disease in patients with systemic lupus erythematosus. However, the relationship between these two conditions is still a subject of controversy. Objectives. Our aim was to investigate the association between migraine and the risk of developing systemic lupus erythematosus through a meta-analysis of case-control studies. Methods. Following the Preferred Reporting Project for Systematic Reviews and Meta-Analysis statement, we conducted a comprehensive search of the following literature databases, including PubMed, Embase, and Web of Science, to identify relevant articles published up to June 2022 using the keywords “migraine” and “systemic lupus erythematosus” as subject headings. If heterogeneity was expected to be low (I2 ≤ 50%), the pooled analysis was performed using a fixed-effects model calculated by the Mantel-Haenszel method. Analysis in this study was conducted using R software (http://www.r-project.org). Results. Six case-control experimental studies involving 908 participants were included in the meta-analysis. The overall combined relative risk of developing systemic lupus erythematosus in patients with migraine, compared to the control group, was 1.69 (95% confidence interval (CI): 1.26 to 2.27). The analysis revealed minimal evidence of heterogeneity and publication bias. Conclusions. Based on our meta-analysis, there is suggestive evidence that patients with migraine may have an elevated risk of developing systemic lupus erythematosus attacks.
背景。偏头痛是系统性红斑狼疮患者常见的一种神经系统疾病。然而，这两种情况之间的关系仍然是一个有争议的话题。目标。我们的目的是通过病例对照研究的荟萃分析来调查偏头痛与发生系统性红斑狼疮风险之间的关系。方法。根据首选报告项目系统评价和荟萃分析声明，我们对以下文献数据库进行了全面搜索，包括PubMed, Embase和Web of Science，以确定截至2022年6月发表的相关文章，主题标题为“偏头痛”和“系统性红斑狼疮”。如果异质性预期较低(i2≤50%)，则使用固定效应模型(由Mantel-Haenszel方法计算)进行合并分析。本研究使用R软件(http://www.r-project.org)进行分析。结果。meta分析包括6项病例对照实验研究，涉及908名参与者。与对照组相比，偏头痛患者发生系统性红斑狼疮的总体综合相对风险为1.69(95%可信区间(CI): 1.26至2.27)。分析显示，异质性和发表偏倚的证据很少。结论。根据我们的荟萃分析，有证据表明偏头痛患者发生系统性红斑狼疮发作的风险较高。
期刊介绍：
Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
