Anorectal mucosal melanoma

IF 0.4 Q4 SURGERY

Seminars in Colon and Rectal Surgery Pub Date : 2023-10-17 DOI:10.1016/j.scrs.2023.100990

Janet Alvarez MD , J. Joshua Smith MD, PhD

引用次数: 0

Abstract

Anorectal mucosal melanoma accounts for less than 1 % of all anorectal malignant tumors and a tendency for delayed diagnosis leads to advanced disease at presentation.¹^,² Due to the rarity of the disease, there are limited prospective trials exploring the optimal treatment strategies. Generally, tumors are surgically excised, with a preference for conservative management with wide local excision. In the past decade, there have been advances with immunotherapy and other targeted therapies. Multiple clinical trials continue exploring neoadjuvant/adjuvant combination treatments in the setting of advanced or unresectable disease.

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肛门直肠粘膜黑色素瘤

肛肠粘膜黑色素瘤占所有肛肠恶性肿瘤的不到1%，并且延迟诊断的趋势导致疾病在出现时进展。1,2由于该疾病的罕见性，探索最佳治疗策略的前瞻性试验有限。一般来说，肿瘤是手术切除的，倾向于保守治疗，局部广泛切除。在过去的十年里，免疫疗法和其他靶向疗法取得了进展。多个临床试验继续探索新辅助/辅助联合治疗在晚期或不可切除疾病的设置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Colon and Rectal Surgery SURGERY-

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Seminars in Colon and Rectal Surgery offers a comprehensive and coordinated review of a single, timely topic related to the diagnosis and treatment of proctologic diseases. Each issue is an organized compendium of practical information that serves as a lasting reference for colorectal surgeons, general surgeons, surgeons in training and their colleagues in medicine with an interest in colorectal disorders.