Susu Guo, Ran Zhang, Yingyu Liu, Qingmei Zhang, Xiaoming Liu, Xiuping Wu, Bing Li
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引用次数: 0
Abstract
Carbon dots (CDs) are a novel type of fluorescent nanoparticles with a particle size smaller than 10 nm. They possess several advantageous properties, including excellent biocompatibility, light stability, water solubility, and low toxicity. CDs have been widely researched in recent years. As a treasure of ancient Chinese science, traditional Chinese medicine (TCM) is rich in various active ingredients and has a variety of pharmacodynamic effects, which have been used for thousands of years. TCM-CDs prepared with TCM as carbon source can create some special functions and then may play a greater medicinal value. The purpose of this review was to engage in an in-depth conversation about the use of TCM-CDs in medical therapy and bioimaging. Firstly, this study provides a comprehensive exploration of different synthesis methods for TCM-CDs, comparing their respective advantages and disadvantages. Subsequently, the intrinsic pharmacological activity of TCM-CDs, encompassing antibacterial, hypoglycemic, hemostatic, anticancer, and anti-inflammatory effects, is mainly discussed, alongside their underlying mechanisms of action. Additionally, investigations into in vitro imaging of diverse cell types and the distribution and uptake of TCM-CDs under in vivo imaging guidance are presented. Finally, the significance of TCM-CD research, key challenges and issues within this field, and future directions for development are summarized and outlined.
碳点（CD）是一种新型的荧光纳米粒子，其粒径小于 10 纳米。它们具有多种优势特性，包括良好的生物相容性、光稳定性、水溶性和低毒性。近年来，CD 已被广泛研究。中药作为中国古代科学的瑰宝，富含多种有效成分，具有多种药效，已有数千年的应用历史。以中药为碳源制备的中药 CD 可以产生一些特殊的功能，进而发挥更大的药用价值。本综述旨在深入探讨中药 CD 在医学治疗和生物成像中的应用。首先，本研究全面探讨了中药 CD 的不同合成方法，比较了它们各自的优缺点。随后，主要讨论了中药活性成分的内在药理活性，包括抗菌、降血糖、止血、抗癌和抗炎作用，以及其潜在的作用机制。此外，还介绍了不同细胞类型的体外成像研究，以及中药 CD 在体内成像引导下的分布和吸收情况。最后，总结并概述了中药活性成分研究的意义、该领域的主要挑战和问题以及未来的发展方向。
期刊介绍：
Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.
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