Clinical profile of febrile encephalopathy patients at a tertiary care hospital in India: A retrospective study

IF 0.4 Q4 CRITICAL CARE MEDICINE
Jitesh Goel, Sanjeev Sengupta, AshishKumar Shukla, Kunal Kishore, Amlan Ghosh
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引用次数: 0

Abstract

Objective: To investigate demography, etiology, and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern India. Methods: This retrospective, observational study included a total of 50 patients (>18 years) who presented with fever and encephalopathy. All patients underwent blood analysis; culture test for blood, urine, sputum, cerebrospinal fluid, and other body fluids; chest and abdominal ultrasonography; neuroimaging; polymerase chain reaction test, and other relevant tests as and when applicable. Results: The mean age of all enrolled patients was (58.0±16.0) years with male to female ratio of 1.27:1. Viral encephalitis was diagnosed in 16 (32%) patients, sepsis-associated encephalitis in 14 (28%), bacterial meningoencephalitis in 8 (16%) and tuberculosis meningoencephalitis in 5 (10%). The mean hospital stay was 10 (4, 17) days. At 6-month follow-up, 10 (20%) patients died, 10 (20%)patients recovered with sequelae (cognitive impairment, critical careneuropathy, etc.), and 30 (60%) patients recovered without sequelae. A statistically significant association was noted between GlasgowComa Scale (<8) and mortality rate (P=0.02). Conclusions: Primary central nervous system infection is the mostfrequent etiology of febrile encephalopathy and viral encephalitisis the most common etiological cause. Accurate, systematic, timelydiagnosis and management are prime factors to reduce mortality andmorbidity.
印度三级医院发热性脑病患者的临床概况:一项回顾性研究
目的:调查人口统计学、病因学和临床概况,并分析在印度东部三级保健中心出现发热性脑病的患者的预后。方法:这项回顾性观察性研究共纳入50例(>18岁)以发热和脑病为表现的患者。所有患者均进行血液分析;血、尿、痰、脑脊液和其他体液培养试验;胸腹超声检查;神经影像;聚合酶链反应测试,以及其他相关测试。结果:所有入组患者的平均年龄为(58.0±16.0)岁,男女比例为1.27:1。病毒性脑炎16例(32%),败血症相关脑炎14例(28%),细菌性脑膜炎8例(16%),结核性脑膜脑炎5例(10%)。平均住院时间为10(4.17)天。随访6个月,10例(20%)患者死亡,10例(20%)患者有后遗症(认知障碍、危重神经病变等)恢复,30例(60%)患者无后遗症恢复。格拉斯哥昏迷评分(<8)与死亡率之间有统计学意义的关联(P=0.02)。结论:原发性中枢神经系统感染是发热性脑病最常见的病因,病毒性脑炎是最常见的病因。准确、系统、及时的诊断和管理是降低死亡率和发病率的主要因素。
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来源期刊
Journal of Acute Disease
Journal of Acute Disease CRITICAL CARE MEDICINE-
自引率
20.00%
发文量
652
审稿时长
12 weeks
期刊介绍: The articles published mainly deal with pre-hospital and hospital emergency medicine, cardiopulmonary-cerebral resuscitation, critical cardiovascular disease, sepsis, severe infection, multiple organ failure, acute and critical diseases in different medical fields, sudden cardiac arrest, Intensive Care Unit (ICU), critical care medicine, disaster rescue medicine (earthquakes, fires, floods, mine disaster, air crash, et al.), acute trauma, acute toxicology, acute heart disease, and related topics. JAD sets up columns for special subjects in each issue.
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