Clinical observation of laparoscopic sleeve gastrectomy and metformin treatment in obese PCOS patients

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-09-13 DOI:10.5937/jomb0-44411

Qingya Ma, Xiaojing He, Zijie Fu, Xiaodong Ren, Ranran Sun, Siqi Zhu, Xiaodong Li, Yahui Bian

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Abstract

Background: to observe the basic metabolic characteristics of obese patients with PCOS, and observe and compare the effect of laparoscopic sleeve gastrectomy and metformin treatment after 3 months. Methods: In January to December 2018, the Second Hospital of Hebei Medical University selected 104 women who were classified as obese with a BMI of 28kg/cm2 or higher and had PCOS. They were divided into obese PCOS group (53 cases) and obese non-pcos group (51 cases). Results: 1. There was no significant difference in waist circumference and WHR between patients who are obese with PCOS and patients who are obese without PCOS (P > 0.05).Obese PCOS patients were significantly higher in AMH, LH/FSH, T, FAI, homa-ir, TG, LDL, apo-b and uric acid than the group of non-PCOS patients who were obese. (P<0.05). The SHBG levels of obese patients with PCOS were obviously lower when contrasted with the levels in obese patients without PCOS (P < 0.05). 2. Body weight, BMI, INS, homa-ir and TG of obese PCOS patients were significantly decreased 3 months after laparoscopic sleeve gastrectomy compared with that before surgery (P < 0.05). After three months of medical treatment with metformin, the patients' HOMA-IR was obviously reduced when contrasted with the pre-treatment HOMA-IR levels (P < 0.05), and there was no significant difference in the improvement degree of homa-ir between the two groups (P > 0.05). Conclusion: 1. Obese patients with PCOS demonstrated higher expression of AMH, LH/FSH, T, SHBG, and FAI when contrasted with the control group. Additionally, they experienced more severe insulin resistance and lipid metabolism disorders. 2. The weight and BMI of obese PCOS patients were significantly decreased after weight loss, while IR and blood lipid were significantly improved, while IR was improved in metformin group, and no significant discrepancy was observed in the degree of improvement of insulin resistance between both groups.

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腹腔镜套筒胃切除术联合二甲双胍治疗肥胖型多囊卵巢综合征的临床观察

背景:观察肥胖多囊卵巢综合征患者的基本代谢特征，并观察比较3个月后腹腔镜袖式胃切除术与二甲双胍治疗的效果。方法:2018年1 - 12月，河北医科大学第二医院选取BMI为28kg/cm2及以上的肥胖女性104例。分为肥胖多囊卵巢综合征组(53例)和肥胖非多囊卵巢综合征组(51例)。结果:1。肥胖合并多囊卵巢综合征患者与肥胖无多囊卵巢综合征患者的腰围和腰宽比无显著差异(P >0.05)。肥胖PCOS患者AMH、LH/FSH、T、FAI、homa-ir、TG、LDL、apo-b、尿酸均显著高于肥胖非PCOS患者组。术中,0.05)。肥胖多囊卵巢综合征患者的SHBG水平明显低于肥胖无多囊卵巢综合征患者(P <0.05)。2. 肥胖型多囊卵巢综合征(PCOS)患者在腹腔镜袖胃切除术后3个月的体重、BMI、INS、homa-ir和TG均较术前显著降低(P <0.05)。经二甲双胍治疗3个月后，患者HOMA-IR较治疗前明显降低(P <0.05)，两组患者homa-ir改善程度差异无统计学意义(P >0.05)强生# x0D;结论:1。与对照组相比，肥胖多囊卵巢综合征患者AMH、LH/FSH、T、SHBG和FAI的表达更高。此外，他们经历了更严重的胰岛素抵抗和脂质代谢紊乱。2. 肥胖PCOS患者减肥后体重、BMI均明显下降，IR、血脂均明显改善，而二甲双胍组IR有所改善，两组胰岛素抵抗改善程度无显著差异。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.