An Insight into the Physicochemical, Drug-likeness, Pharmacokinetics and Toxicity Profile of Kigelia africana (Lam) Bioactive Compounds

Abstract

Kigelia africana plant is multipurpose plant whose therapeutic potential has been thoroughly investigated. The physicochemical, solubilities, ADMET, pharmacological, and drug-like properties of this plant have not been reported in details. This study makes use of the information that is currently known on the chemical make-up of the plant to forecast its overall toxicity as well as the potential for the phytochemicals it contains to be employed in medication discovery. The study also employed free web servers for the lipophilicity, water solubility, drug-likness, bioavailability score, medicinal chemistry and toxicological profiling of the compounds of K. africana. Artemether, a known antimalaria drug was used to validate the potentials of the phytochemicals to serve as precursor to valuable drugs. Findings from our study revealed that a larger percentage of these compounds passed the physicochemical properties analysis, low lipophilicities, high-water solubilities, obeyed the drug-likeness rules, had high gastrointestinal absorption, high blood-barrier permeant, low permeability glycoprotein and hence bioavailable. The toxicological profile additionally showed that majority of the compounds possessed low toxicities and thus can be a potential drug candidate in the drug development industry. The profile of the well-known artemether supported the study's findings that a higher proportion of the K. africana compounds have potential drug-like molecules.