Recent advances in steroidal glycoalkaloid biosynthesis in the genus <i>Solanum</i>

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-25 DOI:10.5511/plantbiotechnology.23.0717b

Ryota Akiyama, Naoyuki Umemoto, Masaharu Mizutani

引用次数: 1

Abstract

Steroidal glycoalkaloids (SGAs) are specialized metabolites found in members of Solanum species, and are also known as toxic substances in Solanum food crops such as tomato (Solanum lycopersicum), potato (Solanum tuberosum), and eggplant (Solanum melongena). SGA biosynthesis can be divided into two main parts: formation of steroidal aglycones, which are derived from cholesterol, and glycosylation at the C-3 hydroxy group. This review focuses on recent studies that shed light on the complete process of the aglycone formation in SGA biosynthesis and structural diversification of SGAs by duplicated dioxygenases, as well as the development of non-toxic potatoes through genome editing using these findings.

查看原文本刊更多论文

Solanum</i>甾体糖生物碱生物合成研究进展

甾体糖生物碱(SGAs)是在茄属植物中发现的特殊代谢物，也被称为茄属粮食作物中的有毒物质，如番茄(茄属)、马铃薯(茄属)和茄子(茄属)。SGA生物合成可分为两个主要部分:甾体苷元的形成(源自胆固醇)和C-3羟基上的糖基化。本文重点综述了近年来研究SGA生物合成中糖元形成的完整过程和通过重复双加氧酶使SGA结构多样化的研究，以及利用这些发现通过基因组编辑开发无毒马铃薯的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.