Mechanochemical difluoromethylation of (thio)phenols and N-heterocycles

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Israel Journal of Chemistry Pub Date : 2023-09-13 DOI:10.1002/ijch.202300109

Joseph Ford, Benjamin Hopkin, Jeroen B. I. Sap, Véronique Gouverneur

引用次数: 0

Abstract

Herein, we report a minimalistic protocol for the solvent-free, mechanochemical difluoromethylation of (thio)phenols and N-heteroarenes using non-ozone depleting chlorodifluoromethyl phenyl sulfone as a difluorocarbene source. This mechanochemical difluoromethylation features a short reaction time, excellent functional group tolerance, and compatibility with complex biologically active scaffolds.

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(硫)酚和N -杂环的机械化学二氟甲基化

在这里，我们报告了一个简单的方案，无溶剂，机械化学二氟甲基化(硫)苯酚和N -杂环芳烃使用非臭氧消耗氯二氟甲基苯基砜作为二氟化苯的来源。这种机械化学的二氟甲基化具有反应时间短、良好的官能团耐受性和与复杂的生物活性支架的相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Israel Journal of Chemistry 化学-化学综合

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.