Biomimetic 3D bioprinting approaches to engineer the tumor microenvironment

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL
Fabiano Bini, Salvatore D’Alessandro, Tarun Agarwal, Daniele Marciano, Serena Duchi, Enrico Lucarelli, Giancarlo Ruocco, Franco Marinozzi, Gianluca Cidonio
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Abstract

With the increasing incidence and mortality rates, cancer remains a major health challenge in the world. Despite advances in therapies and clinical programs, the efficacy of anti-cancer drugs often fails to translate from pre-clinical models to patient clinical trials. To date, pre-clinical cancer models, including two-dimensional cell cultures and animal models, have limited versatility and accuracy in recapitulating the complexity of human cancer. To address these limitations, a growing focus has fostered the development of three-dimensional (3D) tumor models that closely resemble the in vivo tumor microenvironment and heterogeneity. Recent efforts have leveraged bioengineering technologies, such as biofabrication, to engineer new platforms that mimic healthy and diseased organs, aiming to overcome the shortcomings of conventional models, such as for musculoskeletal tissues. Notably, 3D bioprinting has emerged as a powerful tool in cancer research, offering precise control over cell and biomaterial deposition to fabricate architecturally complex and reproducible functional models. The following review underscores the urgent need for more accurate and relevant 3D tumor models, highlighting the advantages of the use of biofabrication approaches to engineer new biomimetics platforms. We provide an updated discussion on the role of bioengineering technologies in cancer research and modeling with particular focus on 3D bioprinting platforms, as well as a close view on biomaterial inks and 3D bioprinting technologies employed in cancer modeling. Further insights into the 3D bioprinting tissue-specific modeling panorama are presented in this paper, offering a comprehensive overview of the new possibilities for cancer study and drug discovery.  
利用仿生3D生物打印技术设计肿瘤微环境
随着发病率和死亡率的增加,癌症仍然是世界上一个主要的健康挑战。尽管治疗和临床项目取得了进展,但抗癌药物的疗效往往无法从临床前模型转化为患者临床试验。迄今为止,临床前癌症模型,包括二维细胞培养和动物模型,在概括人类癌症的复杂性方面具有有限的通用性和准确性。为了解决这些局限性,越来越多的人关注于促进三维(3D)肿瘤模型的发展,这些模型与体内肿瘤微环境和异质性非常相似。最近的努力利用生物工程技术,如生物制造,来设计模拟健康和患病器官的新平台,旨在克服传统模型(如肌肉骨骼组织)的缺点。值得注意的是,3D生物打印已经成为癌症研究的有力工具,可以精确控制细胞和生物材料沉积,以制造结构复杂且可复制的功能模型。下面的综述强调了迫切需要更准确和相关的3D肿瘤模型,强调了使用生物制造方法来设计新的仿生平台的优势。我们提供了关于生物工程技术在癌症研究和建模中的作用的最新讨论,特别关注3D生物打印平台,以及生物材料墨水和3D生物打印技术在癌症建模中的应用。本文提出了对3D生物打印组织特异性建模全景的进一步见解,全面概述了癌症研究和药物发现的新可能性。,,
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
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