Cerebellar neuromodulation impacts reading fluency in young adults

IF 3.6 Q1 LINGUISTICS
Marissa M Lee, Lauren M McGrath, Catherine J Stoodley
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引用次数: 0

Abstract

Abstract The cerebellum is traditionally associated with the control of coordinated movement, but ample evidence suggests that the cerebellum also supports cognitive processing. Consistent with this, right-lateralized posterolateral cerebellar regions are engaged during a range of reading and reading-related tasks, but the specific role of the cerebellum during reading tasks is not clear. Based on the cerebellar contribution to automatizing movement, it has been hypothesized that the cerebellum is specifically involved in rapid, fluent reading. We aimed to determine whether the right posterolateral cerebellum is a specific modulator of reading fluency or whether cerebellar modulation is broader, also impacting reading accuracy, rapid automatized naming, and general processing speed. To do this, we examined the effect of transcranial direct current stimulation (tDCS) targeting the right posterolateral cerebellum (lobules VI/VII) on single-word reading fluency, reading accuracy, rapid automatized naming, and processing speed. Young adults with typical reading development (n = 25; 15 female sex assigned at birth, 10 male sex assigned at birth, aged 18–28 years [M = 19.92 ± 2.04 years]) completed the reading and cognitive measures after 20 min of 2 mA anodal (excitatory), cathodal (inhibitory), or sham tDCS in a within-subjects design. Linear mixed effects models indicated that cathodal tDCS decreased single-word reading fluency scores (d = −0.36, p < 0.05) but did not significantly affect single-word reading accuracy, rapid automatized naming, or general processing speed measures. Our results suggest that the right posterolateral cerebellum is involved in reading fluency, consistent with a broader role of the cerebellum in fast, fluent cognition.
小脑神经调节对年轻人阅读流畅性的影响
小脑传统上与协调运动的控制有关,但充分的证据表明,小脑也支持认知加工。与此一致的是,小脑右侧后外侧区域参与了一系列阅读和阅读相关的任务,但小脑在阅读任务中的具体作用尚不清楚。基于小脑对自动化运动的贡献,有人假设小脑特别参与快速、流畅的阅读。我们的目的是确定右后外侧小脑是否是阅读流畅性的特定调节器,还是小脑的调节范围更广,也会影响阅读准确性、快速自动命名和一般处理速度。为此,我们研究了针对右小脑后外侧(小叶VI/小叶VII)的经颅直流电刺激(tDCS)对单字阅读流畅性、阅读准确性、快速自动命名和处理速度的影响。具有典型阅读发展的年轻人(n = 25;15名出生时指定性别的女性,10名出生时指定性别的男性,年龄在18-28岁[M = 19.92±2.04岁]),在受试者内设计的2 mA电刺激(兴奋性)、阴极(抑制性)或假tDCS 20分钟后完成阅读和认知测试。线性混合效应模型表明,阴极tDCS降低了单字阅读流畅性得分(d = - 0.36, p <0.05),但对单字阅读准确性、快速自动命名或一般处理速度测量没有显著影响。我们的研究结果表明,右后外侧小脑与阅读流畅性有关,这与小脑在快速、流畅的认知中更广泛的作用是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurobiology of Language
Neurobiology of Language Social Sciences-Linguistics and Language
CiteScore
5.90
自引率
6.20%
发文量
32
审稿时长
17 weeks
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