The association of vitamin D level with diabetic peripheral neuropathy: A comparative cross- sectional study

IF 0.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurology Asia Pub Date : 2023-09-01 DOI:10.54029/2023eww

Kazi Majidur Rahaman, Rabani Remli, Hui Jan Tan, Norlaila Mustafa, Mohd Rizal Abdul Manaf, Chen Fei Ng

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引用次数: 0

Abstract

Background & Objective: Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (DM). Vitamin D deficiency has been shown to be prevalent among patients with type 2 DM, particularly in those with DPN. This study aimed to look at the association of serum vitamin D level with peripheral neuropathy in patients with type 2 DM. Methods: This was a comparative cross- sectional study conducted in a tertiary hospital in Malaysia. Fifty diabetic patients with DPN and fifty diabetic patients without DPN were recruited. Serum vitamin D level was determined by measuring 25-hydroxyvitamin D [25(OH)D] level. The patients were clinically assessed and screened with Diabetic Neuropathy Symptoms score. Nerve conduction study was performed for patients with DPN. Results: The serum 25(OH)D level was significantly lower in patients with DPN (11.81 [9.09-18.06] vs 18.63 [11.25-22.63] ng/ml; p=0.006). Multiple logistic regression analysis showed that DPN was significantly associated with higher BMI, longer duration of DM, insulin usage and serum 25(OH)D level. The usage of fibrates had negative association with DPN. Subgroup analysis of the DPN group showed that patients with painful DPN had significant lower serum 25(OH)D level (p<0.001) and the clinical severity of DPN negatively correlated with serum 25(OH)D level (p=0.015). Conclusion: Vitamin D deficiency is associated with DPN in patients with type 2 DM. In addition, patients with painful DPN tend to have significantly lower serum 25(OH)D level.

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维生素D水平与糖尿病周围神经病变的关系:一项比较横断面研究

背景,目的:糖尿病周围神经病变(DPN)是2型糖尿病(DM)的常见并发症。维生素D缺乏症已被证明在2型糖尿病患者中普遍存在，特别是在DPN患者中。本研究旨在观察血清维生素D水平与2型糖尿病患者周围神经病变的关系。方法:这是一项在马来西亚一家三级医院进行的比较横断面研究。我们招募了50例合并DPN的糖尿病患者和50例未合并DPN的糖尿病患者。采用25-羟基维生素D [25(OH)D]测定血清维生素D水平。采用糖尿病神经病变症状评分对患者进行临床评估和筛查。对DPN患者进行神经传导研究。结果:DPN患者血清25(OH)D水平显著低于前者(11.81 [9.09-18.06]vs . 18.63 [11.25-22.63] ng/ml;p = 0.006)。多元logistic回归分析显示，DPN与较高的BMI、较长的糖尿病病程、胰岛素使用和血清25(OH)D水平显著相关。贝特类药物的使用与DPN呈负相关。DPN组亚组分析显示，疼痛型DPN患者血清25(OH)D水平显著降低(p < 0.001)， DPN临床严重程度与血清25(OH)D水平呈负相关(p=0.015)。结论:维生素D缺乏与2型DM患者DPN相关，且疼痛型DPN患者血清25(OH)D水平明显降低。

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来源期刊

Neurology Asia CLINICAL NEUROLOGY-

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Neurology Asia (ISSN 1823-6138), previously known as Neurological Journal of South East Asia (ISSN 1394-780X), is the official journal of the ASEAN Neurological Association (ASNA), Asian & Oceanian Association of Neurology (AOAN), and the Asian & Oceanian Child Neurology Association. The primary purpose is to publish the results of study and research in neurology, with emphasis to neurological diseases occurring primarily in Asia, aspects of the diseases peculiar to Asia, and practices of neurology in Asia (Asian neurology).