TRENDS IN POISONING CASES: AN AUTOPSY-BASED STUDY AT KHYBER MEDICAL COLLEGE, PESHAWAR

Journal of Medical Sciences Pub Date : 2023-08-23 DOI:10.52764/jms.23.31.3.12

Noor ul Baqi, Faiza Nadeem, Muhammad Wasif, Syed Ahsan Ali, Saima Aziz

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Abstract

Objective To determine trends of poisoning cases in autopsy examinations conducted at Khyber Medical College, Peshawar. Materials and Methods This descriptive cross-sectional study enrolled 262 cases of poisoning presented for autopsy at the Department of Forensic Medicine, Khyber Medical College from 1st January 2018 to 31st December 2022. All poison-based autopsy cases of any age and gender were included in the study. Cases with Incomplete documentation and referred from other districts were excluded from the study. Results: Our study showed males 228/262 (87%) were more prevalent than females 34/262 (13%). Moreover, 21-30 years of age were 82/262 (31.3%)individuals. Out of 262 subjects, 50.4% (n=132) were poisoned with a single drug, though 49.6% (n=130) were having multiple drugs. The poisons found in the study were morphine (58.0%, 152), methamphetamines (34.4%, 90), benzodiazepines (34.4%, 90), Tetrahydrocannabinol (19.8%, 52), amphetamines, (15.6%, 41), phosphine (8.8%, 23), Tricyclic antidepressants (8.4%, 22), carbon monoxide (3.8%, 10), methyl alcohol (1.5%, 4), ethyl alcohol (1.1%, 3), propranolol (0.8%, 2), arsenic (0.4%, 1) and tissue paper (0.4%, 1). The trends of poisoning have been looked through the period of 5 years, indicating the use of morphine, amphetamines, and methamphetamines were escalating in the meantime, whereas the frequency of usage of benzodiazepines remain sustained Conclusion: Our study concluded that poisoning was found more prevalent in males in the middle age group. In addition, the analysis of the last five years revealed that trends of morphine and methamphetamine poisoning increased while phosphine was found to be decreased for the cause of death determination. Keywords: Trends, Poisoning, Autopsy

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中毒病例的趋势:白沙瓦开伯尔医学院基于尸体解剖的研究

目的了解白沙瓦开伯尔医学院尸检中中毒病例的变化趋势。本描述性横断面研究纳入了2018年1月1日至2022年12月31日在开伯尔医学院法医学系尸检的262例中毒病例。该研究包括所有年龄和性别的毒物尸检病例。文献资料不完整及从其他地区转介的病例被排除在研究之外。结果:男性228/262(87%)高于女性34/262(13%)。21 ~ 30岁占82/262(31.3%)。262例受试者中，50.4% (n=132)为单一药物中毒，49.6% (n=130)为多种药物中毒。研究中发现的中毒药物为吗啡(58.0%，152)、甲基苯丙胺(34.4%，90)、苯二氮平类药物(34.4%，90)、四氢大麻酚(19.8%，52)、安非他明(15.6%，41)、磷化氢(8.8%，23)、三环类抗抑郁药(8.4%，22)、一氧化碳(3.8%，10)、甲醇(1.5%，4)、乙醇(1.1%，3)、心得安(0.8%，2)、砷(0.4%，1)、薄纸(0.4%，1)。与此同时，苯二氮卓类药物的使用频率保持不变，而安非他命、甲基苯丙胺的使用频率呈上升趋势。结论:中年男性中毒更为普遍。此外，对过去五年的分析表明，吗啡和甲基苯丙胺中毒的趋势有所增加，而确定死亡原因的磷化氢则有所减少。关键词:趋势，中毒，尸检

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Journal of Medical Sciences

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