Isosorbide Dinitrate Orally Disintegrating Films Cyclodextrins/HPMC Based: Mechanical, Optical, and Physicochemical Studies

Abstract

HIGHLIGHTS Orally films Cyclodextrins/HPMC based films were prepared by solvent casting. Films for oral delivery of ISDN were prepared by 32 factorial designs. Mechanical, optical, and dissolution properties were evaluated. The experimental design allowed to optimize the formulations. The best formulation was obtained by means of the desirability function.