Effect of Detector Placement on Joint Estimation in X-Ray Fluorescence Emission Tomography

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hadley DeBrosse;Ling Jian Meng;Patrick La Rivière
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引用次数: 0

Abstract

Imaging the spatial distribution of low concentrations of metal is a growing problem of interest with applications in medical and material sciences. X-ray fluorescence emission tomography (XFET) is an emerging metal mapping imaging modality with potential sensitivity improvements and practical advantages over other methods. However, XFET detector placement must first be optimized to ensure accurate metal density quantification and adequate spatial resolution. In this work, we first use singular value decomposition of the imaging model and eigendecomposition of the object-specific Fisher information matrix to study how detector arrangement affects spatial resolution and feature preservation. We then perform joint image reconstructions of a numerical gold phantom. For this phantom, we show that two parallel detectors provide metal quantification with similar accuracy to four detectors, despite the resulting anisotropic spatial resolution in the attenuation map estimate. Two orthogonal detectors provide improved spatial resolution along one axis, but underestimate the metal concentration in distant regions. Therefore, this work demonstrates the minor effect of using fewer, but strategically placed, detectors in the case where detector placement is restricted. This work is a critical investigation into the limitations and capabilities of XFET prior to its translation to preclinical and benchtop uses.
探测器位置对 X 射线荧光发射断层成像中联合估算的影响
对低浓度金属的空间分布进行成像是医学和材料科学领域日益关注的问题。X 射线荧光发射断层扫描(XFET)是一种新兴的金属绘图成像方式,与其他方法相比,它具有潜在的灵敏度改进和实用优势。然而,XFET 探测器的放置必须首先进行优化,以确保准确的金属密度量化和足够的空间分辨率。在这项工作中,我们首先使用成像模型的奇异值分解和特定对象费舍尔信息矩阵的高分解来研究探测器的布置如何影响空间分辨率和特征保存。然后,我们对一个数值黄金模型进行了联合图像重建。在该模型中,我们发现尽管衰减图估算的空间分辨率各向异性,但两个平行探测器提供的金属量化精度与四个探测器相似。两个正交探测器沿一条轴线提高了空间分辨率,但低估了远处区域的金属浓度。因此,这项工作展示了在探测器位置受限的情况下,使用较少但有策略地放置探测器的微小效果。在将 XFET 应用于临床前和台式设备之前,这项工作是对其局限性和能力的重要研究。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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