Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study

IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Taibah University Medical Sciences Pub Date : 2023-10-07 DOI:10.1016/j.jtumed.2023.09.006

RM Sonny Sasotya MD , Arieff Kustiandi MD , Yudi Mulyana Hidayat MD , Jusuf Sulaeman Effendi MD , Wiryawan Permadi MD , Ali Budi Harsono MD , Ayu Insafi Mulyantari MD , Bethy S. Hernowo MD

{"title":"Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study","authors":"RM Sonny Sasotya MD , Arieff Kustiandi MD , Yudi Mulyana Hidayat MD , Jusuf Sulaeman Effendi MD , Wiryawan Permadi MD , Ali Budi Harsono MD , Ayu Insafi Mulyantari MD , Bethy S. Hernowo MD","doi":"10.1016/j.jtumed.2023.09.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN).</p></div><div><h3>Methods</h3><p>This is a cross-sectional study involved 61 specimens of HM (n = 37, 60.7%) and GTN (n = 24, 39.3%) was collected from the biopsy. An immunohistochemistry was used to asses the VDR expression. Student's t-test and Mann–Whitney test were used to compare the expression of VDR, including VDR staining intensity, VDR distribution, and histoscore, between HM and GTN tissue specimens.</p></div><div><h3>Results</h3><p>No significant differences in age and parity were noted between patients with HM or GTN (p > 0.05). The VDR staining intensity of GTN tissue specimens was significantly lower than that of HM tissue specimens (2.3 ± 0.8 vs. 2.8 ± 0.5, p = 0.008). In addition, the histoscore for GTN tissues was significantly lower than that for HM tissues (7.3 ± 3.2 vs. 9.4 ± 28, p = 0.016). However, no significant differences in VDR distribution between GTN and HM tissues were observed (3.3 ± 0.8 vs. 3.3 ± 1.0, p = 0.525).</p></div><div><h3>Conclusion</h3><p>Low VDR expression is associated with GTN, whereas high VDR expression is associated with HM, suggesting that the expression of VDR may regulate the severity of gestational trophoblastic disease.</p></div>","PeriodicalId":46806,"journal":{"name":"Journal of Taibah University Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1658361223001464/pdfft?md5=d97e11dffe8ff4aadd98940d5160b254&pid=1-s2.0-S1658361223001464-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Taibah University Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1658361223001464","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN).

Methods

This is a cross-sectional study involved 61 specimens of HM (n = 37, 60.7%) and GTN (n = 24, 39.3%) was collected from the biopsy. An immunohistochemistry was used to asses the VDR expression. Student's t-test and Mann–Whitney test were used to compare the expression of VDR, including VDR staining intensity, VDR distribution, and histoscore, between HM and GTN tissue specimens.

Results

No significant differences in age and parity were noted between patients with HM or GTN (p > 0.05). The VDR staining intensity of GTN tissue specimens was significantly lower than that of HM tissue specimens (2.3 ± 0.8 vs. 2.8 ± 0.5, p = 0.008). In addition, the histoscore for GTN tissues was significantly lower than that for HM tissues (7.3 ± 3.2 vs. 9.4 ± 28, p = 0.016). However, no significant differences in VDR distribution between GTN and HM tissues were observed (3.3 ± 0.8 vs. 3.3 ± 1.0, p = 0.525).

Conclusion

Low VDR expression is associated with GTN, whereas high VDR expression is associated with HM, suggesting that the expression of VDR may regulate the severity of gestational trophoblastic disease.

查看原文本刊更多论文

维生素D受体在葡萄胎和妊娠滋养细胞瘤中的表达:横断面研究

目的维生素D受体(VDR)在多种肿瘤中发挥抗癌作用。本研究的目的是探讨VDR在葡萄胎(HM)和妊娠滋养细胞瘤(GTN)患者中的表达。方法横断面研究61例HM标本(n = 37, 60.7%)和GTN标本(n = 24, 39.3%)。免疫组化检测VDR表达。采用Student's t检验和Mann-Whitney检验比较HM和GTN组织标本中VDR的表达，包括VDR染色强度、VDR分布和histoscore。结果HM和GTN患者的年龄和胎次无显著差异(p >0.05)。GTN组织标本的VDR染色强度显著低于HM组织标本(2.3±0.8 vs. 2.8±0.5,p = 0.008)。此外，GTN组的组织评分显著低于HM组(7.3±3.2 vs. 9.4±28,p = 0.016)。而GTN与HM组织的VDR分布无显著差异(3.3±0.8 vs. 3.3±1.0,p = 0.525)。结论VDR低表达与GTN相关，而VDR高表达与HM相关，提示VDR的表达可能调节妊娠滋养细胞疾病的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊