Survival Analysis of Multi-Drug Resistant Tuberculosis Patients in North Sumatra

Pesona Dessritina, Dien Gusta Aggraini Nursal, Syafrawati Syafrawati
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Abstract

Background: The severity and ease of spread of MDR-TB have caused this disease to become an epidemic in various countries. WHO has also launched an international program "End TB" which until now has not even reached half of the target. Indonesia is already in the third highest position after India and China with a CFR of 0.11% and North Sumatra Province is already at the 6th highest level in Indonesia and the highest on the island of Sumatra.Purpose : The purpose of this study was to see the survival of MDR-TB patients in North Sumatra Province.Methods: The method in this study used a retrospective cohort design with secondary data on MDR-TB cases for 2020 – 2022. The sample used was total sampling with the condition that it met the sample criteria, namely complete data and treatment results. The analysis was carried out using univariate, Kaplan-Meier, bivariate analysis using the logrank test and multivariate with full model logistic regression.Results: The results obtained from a total of 664 cases (26.81%) died and (73.19%) survived. The variables related to survival in MDR-TB patients were age (p = 0.000 HR (Hazard Ratio) 1.88) and HIV status (p = 0.001 HR 1.40). The dominant variable related to survival is age (p = 0.000 HR 0.64).Conclusion: based on statistical tests, age and HIV status had a significant relationship with survival, while gender, OAT resistance, history of DM, history of treatment and treatment delays had no significant relationship based on statistical tests in this study.
北苏门答腊岛耐多药结核病患者的生存分析
背景:耐多药结核病的严重程度和传播的便利性使这种疾病在许多国家成为流行病。世卫组织还启动了一项“终止结核病”国际规划,到目前为止,该规划甚至还没有达到目标的一半。印度尼西亚已经排在印度和中国之后的第三位,CFR为0.11%,北苏门答腊省已经排在印度尼西亚的第六位,也是苏门答腊岛上最高的。目的:本研究的目的是了解北苏门答腊省耐多药结核病患者的生存率。方法:本研究采用回顾性队列设计,收集2020 - 2022年耐多药结核病病例的次要数据。使用的样本为全抽样,符合样本标准,即完整的数据和处理结果。采用单因素Kaplan-Meier分析,双因素logrank检验分析,多因素全模型logistic回归分析。结果:664例死亡(26.81%),存活(73.19%)。与耐多药结核病患者生存相关的变量是年龄(p = 0.000 HR(危险比)1.88)和艾滋病毒状况(p = 0.001 HR 1.40)。与生存率相关的主要变量是年龄(p = 0.000 HR 0.64)。结论:经统计检验,年龄、HIV感染状况与生存率有显著关系,性别、OAT耐药、糖尿病史、治疗史、治疗延误与生存率无显著关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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