Type 2 reaction associated sensorineural hearing loss in a drug resistant lepromatous leprosy patient: A case report

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.4103/1995-7645.386077

Harpreet Singh Pawar, Itu Singh, Harish Kumar Sagar

引用次数: 0

Abstract

Rationale: Leprosy, a chronic granulomatous disease often present clinically as erythema nodosum leprosum, a type 2 reaction. The involvement of cochlear part of audiovestibular system is a rarity. Patient concerns: A 26-year-old male patient with lepromatous leprosy developed bilateral sensorineural hearing loss (SNHL) during type 2 reactional episode. Diagnosis: Recurrent erythema nodosum leprosum in rifampicin-resistant lepromatous leprosy. Interventions: Corticosteroids and second-line multidrug therapy. Outcomes: The patient improved significantly and was further referred for management of psychosocial impact due to sensorineural hearing loss. Lessons: The hearing impairment is a rare complication of type 2 reaction. Any patient with suspected cranial nerve involvement should essentially be screened by tuning fork tests for early detection of hearing impairment and offer timely intervention as required. All high bacteriological index cases should be investigated for antimicrobial resistance in high endemic areas.

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1例耐药麻风患者2型反应相关感音神经性听力损失

理由:麻风，一种慢性肉芽肿性疾病，临床上常表现为麻风结节性红斑，2型反应。耳蜗部分受累于听前庭系统是罕见的。患者关注:一名26岁的男性麻风病患者在2型反应性发作期间出现双侧感音神经性听力损失(SNHL)。诊断:利福平耐药的麻风性麻风结节性红斑复发。干预措施:皮质类固醇和二线多药治疗。结果:患者明显改善，并进一步转介治疗因感音神经性听力损失引起的社会心理影响。经验教训:听力障碍是2型反应的罕见并发症。任何怀疑脑神经受累的患者，基本上都应该通过音叉试验进行筛选，以便早期发现听力障碍，并根据需要及时进行干预。在高流行地区，应对所有细菌学指数高的病例进行抗菌药物耐药性调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.