Diagnostic Accuracy of Cord Blood Bilirubin in Predicting Neonatal Hyperbilirubinemia, Taking Neonatal Hyperbilirubinemia within One Week of Birth as Gold Standard

Journal of Biology and Life Science Pub Date : 2023-10-05 DOI:10.37185/lns.1.1.347

Maryam Majeed, Daniyal Ahmed, Danish Hanif, Hamna Khaliq, Ali Ahmad, Zunaira Asghar Awan

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Abstract

Objective: To determine the diagnostic accuracy of cord blood bilirubin in predicting neonatalhyperbilirubinemia, taking neonatal hyperbilirubinemia within one week of birth as the gold standard.Study Design: Across-sectional study.Place and Duration of Study: The Study was conducted at the Department of Pediatric Medicine, Sheikh Zayed Hospital, Rahim Yar Khan, Pakistan from 7 September 2020 to 6 March 2021.Methods: A total of 366 term neonates of both gendersgenders were included. Neonates with congenital hypothyroidism, neonatal hepatitis, biliary atresia, and sepsis were excluded. After getting informed consent from parents, a cord blood sample was taken and sent to the institutional laboratory for measuring total bilirubin levels, and neonatal hyperbilirubinemia (yes/no) was noted. All neonates were followed by the researcher for one week and neonatal hyperbilirubinemia was noted.Results: The study yielded 193 true positive and 14 false positive cases, along with 7 false negative and 152 true negative cases, with a statistically significant p-value of 0.0001. Overall, the diagnostic accuracy of cord blood bilirubin in predicting neonatal hyperbilirubinemia, using neonatal hyperbilirubinemia within one week of birth as the gold standard, was found to be 96.50% for sensitivity, 91.57% for specificity, 93.24% for positive predictive value, 95.60% for negative predictive value, and 94.26% for diagnostic accuracy.Conclusion: This study has shown that cord blood bilirubin has a rather good diagnostic accuracy for predicting newborn hyperbilirubinemia. How to cite this: Majeed M, Ahmed D, Hanif D, Khaliq H, Ahmad A, Khan ZA. Diagnostic Accuracy of Cord Blood Bilirubin in Predicting Neonatal Hyperbilirubinemia, Taking Neonatal Hyperbilirubinemia within One Week of Birth as Gold Standard. Life and Science. 2023; 4(4): 401-409. doi: http://doi.org/10.37185/LnS.1.1.347

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脐带血胆红素预测新生儿高胆红素血症的诊断准确性，以出生1周内新生儿高胆红素血症为金标准

目的:以新生儿出生1周内高胆红素血症为金标准，探讨脐带血胆红素对新生儿高胆红素血症的诊断准确性。研究设计:横断面研究。研究地点和时间:该研究于2020年9月7日至2021年3月6日在巴基斯坦拉希姆亚尔汗谢赫扎耶德医院儿科医学系进行。方法:对366例足月新生儿(男女)进行分析。排除有先天性甲状腺功能减退、新生儿肝炎、胆道闭锁和败血症的新生儿。在获得父母的知情同意后，采集脐带血样本并送到机构实验室测量总胆红素水平，并记录新生儿高胆红素血症(是/否)。研究人员对所有新生儿进行了为期一周的随访，发现新生儿高胆红素血症。结果:本研究真阳性193例，假阳性14例，假阴性7例，真阴性152例，p值为0.0001，差异有统计学意义。总体而言，以出生1周内新生儿高胆红素血症为金标准，脐带血胆红素预测新生儿高胆红素血症的诊断准确率为敏感性96.50%，特异性91.57%，阳性预测值93.24%，阴性预测值95.60%，诊断准确率94.26%。结论:脐带血胆红素对预测新生儿高胆红素血症具有较好的诊断准确性。如何引用:Majeed M, Ahmed D, Hanif D, Khaliq H, Ahmad A, Khan ZA。脐带血胆红素预测新生儿高胆红素血症的诊断准确性，以出生1周内新生儿高胆红素血症为金标准。生命与科学。2023;4(4): 401 - 409。doi: http://doi.org/10.37185/LnS.1.1.347

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Journal of Biology and Life Science

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