Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer

IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY
Jianzhong Chen, Weifeng Li, Xinyuan Tang, Zhibin Wang, Liang Xu, Qiuming Liu
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引用次数: 0

Abstract

Background: To explore the predictive value of vascular endothelial growth factor (VEGF)-C and D combined with ultrasonic pathological features for nonsentinel lymph node (NSLN) metastasis in positive sentinel lymph nodes (SLNs) early-stage breast cancer. Methods: To review the clinical data of 170 SLN-positive early breast cancer patients. We examined VEGF-C and D positive expression in cancerous and paraneoplastic tissues and counted ultrasound and pathological features. Results: The rate of VEGF-C and D positivity in cancer tissues was higher than that in paracancerous tissues (p < 0.05). The rates of VEGF-C and D positivity in the cancer tissues with vascular infiltration, number of SLN positives >2, proportion of SLN positives >0.5, burr sign on ultrasound, and NSLN metastasis were higher than those of patients without vascular infiltration, number of SLN positives ≤2, proportion of SLN positives ≤0.5, no burr sign, and no NSLN metastasis, respectively (p < 0.05). The results also showed that the presence of vascular infiltration and burr sign, a high number of SLN positivity, the percentage of SLN positivity >0.5, VEGF-C and D positivity were all NSLN metastasis independent risk factors for metastasis (p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) for VEGF-C and D combined with ultrasound and pathological features to predict NSLN metastasis was the highest. Conclusions: The ultrasound and pathological features of SLN-positive early breast cancer patients, such as vascular infiltration, VEGF-C and D positivity, were all independent risk factors for NSLN metastasis, and VEGF-C and D combined with ultrasound and pathological features had high predictive efficacy for NSLN metastasis. It provides reliable indicators to screen for NSLN metastasis in a high-risk group from SLN-positive patients with early-stage breast cancer.
VEGF-C、D结合超声病理特征对sln阳性早期乳腺癌非前哨淋巴结转移的预测价值
背景:探讨血管内皮生长因子(VEGF)-C、D结合超声病理特征对早期乳腺癌阳性前哨淋巴结(sln)非前哨淋巴结(NSLN)转移的预测价值。方法:回顾性分析170例sln阳性早期乳腺癌患者的临床资料。我们检测了VEGF-C和D在癌组织和副肿瘤组织中的阳性表达,并计算了超声和病理特征。结果:肿瘤组织中VEGF-C和vegf - D的阳性率高于癌旁组织(p <0.05)。血管浸润癌组织中VEGF-C和vegf - D的阳性率、SLN阳性数≤2、SLN阳性比例≤0.5、超声毛刺征和NSLN转移的比例分别高于无血管浸润癌组织、SLN阳性数≤2、SLN阳性比例≤0.5、无毛刺征和无NSLN转移的患者(p <0.05)。结果还显示,血管浸润和毛刺征象的存在、SLN阳性的高数量、SLN阳性的百分比>0.5、VEGF-C和D阳性均是NSLN转移的独立危险因素(p <0.05)。受试者工作特征(ROC)曲线分析显示,VEGF-C和vegf - D结合超声和病理特征预测NSLN转移的ROC曲线下面积(AUC)最高。结论:sln阳性早期乳腺癌患者的超声及病理特征如血管浸润、VEGF-C、D阳性等均为NSLN转移的独立危险因素,VEGF-C、D联合超声及病理特征对NSLN转移具有较高的预测效果。为筛选sln阳性的早期乳腺癌患者中高危人群的NSLN转移提供了可靠的指标。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
241
审稿时长
1 months
期刊介绍: CEOG is an international, peer-reviewed, open access journal. CEOG covers all aspects of Obstetrics and Gynecology, including obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine. All submissions of cutting-edge advances of medical research in the area of women''s health worldwide are encouraged.
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