Ultrasonic assisted natural deep eutectic solvents as a green and efficient approach for extraction of hydroxytyrosol from olive leaves†

Industrial Chemistry & Materials Pub Date : 2023-09-15 DOI:10.1039/D3IM00055A

Mingming Hu, Bao Han, Lin Xie, Beibei Lu, De Bai, Nuo Shi, Ya Liao, Yan Wang, Ling Liu, Shaojun Wu, Runrui Lan, Xiaomei Lei, Ci Shi, Danhua Huang, Yuanbin Li, Lin Lin and Jiaheng Zhang

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Abstract

In this study, an ultrasonic assisted natural deep eutectic solvent (DES) was used to extract hydroxytyrosol (HT) from olive leaves. The optimal extraction conditions of the MaPa-4 concentration, extraction time and solid–liquid ratio were obtained by single factor experiments. The formation mechanism of MaPa and its interaction with HT were analyzed by FTIR, ¹H-NMR and density functional theory (DFT) calculation. Then, MaPa-4 and water extracts obtained under the optimal extraction conditions were selected for a series of efficacy tests. MaPa-4 extract demonstrated low cytotoxicity, good biocompatibility, and excellent anti-inflammatory and bacteriostatic properties. Overall, MaPa-4, as an environmentally friendly and efficient solvent, was combined with ultrasound treatment to develop an efficient, green and feasible method to extract HT from olive leaves.

Keywords: Hydroxytyrosol; Deep eutectic solvent; Single-factor experiment; Bacteriostatic; Anti-inflammatory; Antioxidant.

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超声波辅助天然深共晶溶剂作为从橄榄叶中提取羟基酪醇的绿色高效方法†。

本研究采用超声波辅助天然深共晶溶剂（DES）从橄榄叶中提取羟基酪醇（HT）。通过单因素实验获得了 MaPa-4 浓度、萃取时间和固液比的最佳萃取条件。通过傅立叶变换红外光谱、1H-NMR 和密度泛函理论（DFT）计算分析了 MaPa 的形成机理及其与 HT 的相互作用。然后，选择在最佳提取条件下获得的 MaPa-4 和水提取物进行了一系列药效测试。结果表明，MaPa-4提取物具有较低的细胞毒性、良好的生物相容性以及出色的抗炎和抑菌特性。总之，MaPa-4作为一种环保高效的溶剂，与超声处理相结合，开发出了一种高效、绿色、可行的从橄榄叶中提取羟基酪醇的方法：羟基酪醇；深共晶溶剂；单因素实验；抑菌；消炎；抗氧化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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