Plant-based approaches for rheumatoid arthritis regulation: Mechanistic insights on pathogenesis, molecular pathways and delivery systems

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2023-01-01 DOI:10.1615/critrevtherdrugcarriersyst.2023048324

Anita Bhoi, Shradha Devi Dwivedi, Deependra Singh, Sahu Keshavkant, Manju Singh

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引用次数: 0

Abstract

Purpose: Rheumatoid Arthritis (RA) is classified as a chronic inflammatory autoimmune disorder that is associated with a varied range of immunological changes, synovial hyperplasia, cartilage destructions, as well as bone erosion. Even though many conventional drugs are suggested by a medical practitioner such as DMARDs, NSAIDs, glucocorticoids, etc. to treat RA, but, they have allied with various side effects. Therefore, this study tries to compile the most recent research on how plant-based compounds/nano-formulations can combat RA with minimal or no adverse effects. Methods: Databases including Google, Science Direct, Google Scholar, Web of Science, PubMed, Scopus, and Research Gate have been looked through for potentially existing research with the goal of discovering the latest progress on multiple viewpoints of phyto-compounds over RA. Results: In order to decrease the generation of pro-inflammatory cytokines, many phyto-compounds have been reported that regulate cell cycle arrest, FLS proliferation, autophagy, apoptosis, and numerous signaling pathways. Also, the therapeutic difficulties and clinical usefulness of nano-delivery systems are investigated. Conclusions: A tailored approach for treating inflamed tissue may possibly improve the therapeutic efficacy of the drug while reducing its systemic adverse effects. Additionally, the growing herbal revolution has led to the invention of new methods for delivering poorly soluble herbal bioactives and plant extracts to improve their efficacy at targeted inflamed synovial sites.

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植物性类风湿关节炎的调控方法:发病机制、分子通路和传递系统的机制见解

目的:类风湿关节炎(RA)被归类为一种慢性炎症性自身免疫性疾病，与各种免疫变化、滑膜增生、软骨破坏以及骨侵蚀有关。尽管医生建议许多常规药物如DMARDs、非甾体抗炎药、糖皮质激素等治疗类风湿性关节炎，但它们都有各种副作用。因此，本研究试图汇编关于植物基化合物/纳米制剂如何在最小或没有副作用的情况下对抗类风湿性关节炎的最新研究。方法:通过Google、Science Direct、Google Scholar、Web of Science、PubMed、Scopus、Research Gate等数据库查找潜在的现有研究，从多个角度发现植物化合物治疗类风湿性关节炎的最新进展。结果:为了减少促炎细胞因子的产生，许多植物化合物被报道可以调节细胞周期阻滞、FLS增殖、自噬、凋亡和许多信号通路。此外，研究了纳米递送系统的治疗困难和临床用途。结论:治疗炎症组织的量身定制方法可能提高药物的治疗效果，同时减少其全身不良反应。此外，不断发展的草药革命已经导致了新方法的发明，用于输送难溶性草药生物活性物质和植物提取物，以提高其在靶向炎症滑膜部位的功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.