Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques

Q3 Agricultural and Biological Sciences

HAYATI Journal of Biosciences Pub Date : 2023-10-22 DOI:10.4308/hjb.31.1.145-152

Lis Rosmanah, Uus Saepuloh, Sela Septima Mariya, Irma Herawati Suparto, Wasmen Manalu, Adi Winarto, Huda Shalahudin Darusman

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引用次数: 0

Abstract

Amyloid plaques and Neurofibrillary Tangles (NFTs) are known to be key pathological features of Alzheimer disease. To gain a better understanding of this disease, studies were carried out on the Indonesian primates, the long-tailed macaques, using a spontaneous Alzheimer's disease model. Examining and identifying genetic markers involved in plaque formation and NFTs in long-tailed macaques is necessary to reveal their physiological processes. In this study, the expression of genes involved in the development of amyloid plaque (Amyloid Precursor Protein (APP)) and those that control the phosphorylation of tau protein (CDK5 and AKT1) was examined in the long-tailed macaque brain. This study showed that APP, CDK5, and AKT1 may potentially be developed as genetic markers of Alzheimer's disease. Long-tailed macaques exhibited the development of amyloid plaque in the aging brain based on the analysis of the gene expression profile of its biomarker. Furthermore, long-tailed macaques can be optimized for neurodegenerative models.

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APP、CDK5和AKT1基因在长尾猕猴大脑中与阿尔茨海默病相关的表达

淀粉样斑块和神经原纤维缠结(nft)是阿尔茨海默病的主要病理特征。为了更好地了解这种疾病，研究人员使用自发性阿尔茨海默病模型，对印度尼西亚灵长类动物——长尾猕猴进行了研究。研究和鉴定与长尾猕猴斑块形成和nft相关的遗传标记是揭示其生理过程的必要条件。在这项研究中，研究人员检测了长尾猕猴大脑中参与淀粉样蛋白斑块发育的基因(淀粉样蛋白前体蛋白(APP))和控制tau蛋白磷酸化的基因(CDK5和AKT1)的表达。本研究表明APP、CDK5和AKT1可能被开发为阿尔茨海默病的遗传标记。通过对长尾猕猴大脑中淀粉样斑块生物标志物基因表达谱的分析，发现长尾猕猴大脑衰老过程中出现了淀粉样斑块。此外，长尾猕猴可以优化为神经退行性模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HAYATI Journal of Biosciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： HAYATI Journal of Biosciences (HAYATI J Biosci) is an international peer-reviewed and open access journal that publishes significant and important research from all area of biosciences fields such as biodiversity, biosystematics, ecology, physiology, behavior, genetics and biotechnology. All life forms, ranging from microbes, fungi, plants, animals, and human, including virus, are covered by HAYATI J Biosci. HAYATI J Biosci published by Department of Biology, Bogor Agricultural University, Indonesia and the Indonesian Society for Biology. We accept submission from all over the world. Our Editorial Board members are prominent and active international researchers in biosciences fields who ensure efficient, fair, and constructive peer-review process. All accepted articles will be published on payment of an article-processing charge, and will be freely available to all readers with worldwide visibility and coverage.