erum interleukin content and lipid metabolism in cows with subclinical ketosis

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice Pub Date : 2023-01-01 DOI:10.21521/mw.6820

DMYTRO KIBKAŁO, OLGA TYMOSZENKO, HALINA WIKULINA

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Abstract

This paper analyses the diagnostic utility of interleukins (1, 4, 6) and lipid metabolism products (cholesterol, triacylglycerols, lipoprotein fractions) in subclinical ketosis in cows. It was found that serum levels of proinflammatory (IL-1 and IL-6) and anti-inflammatory (IL-4) interleukins in cows with ketosis did not differ from those in clinically healthy animals. This therefore indicates the absence of inflammation in the subclinical form of ketosis. These data were also confirmed by normal α1- and α2-globulin levels. IL-6 is known to increase the synthesis of acute phase inflammatory proteins. There was no significant difference in the IL-4 content between the experimental and control groups of cows. In the subclinical form of ketosis in cows, abnormalities in lipid and lipoprotein metabolism were detected in the form of hypertriglyceridaemia and hyperlipoproteinaemia with very low-density lipoproteins, an increase in low-density lipoproteins, and a decrease in very high-density lipoproteins. This was verified by similar changes in β-lipoprotein levels and lipoprotein fractions and was specific to the first stage of lipomobilisation syndrome.

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亚临床酮症奶牛血清白介素含量与脂质代谢

本文分析了白介素(1,4,6)和脂质代谢产物(胆固醇、甘油三酯、脂蛋白)在奶牛亚临床酮症中的诊断价值。发现酮症奶牛血清中促炎(IL-1、IL-6)和抗炎(IL-4)白介素水平与临床健康动物无显著差异。因此，这表明在亚临床形式的酮症中没有炎症。α1-和α2-球蛋白水平正常也证实了这些数据。已知IL-6可以增加急性期炎症蛋白的合成。试验组与对照组奶牛IL-4含量差异不显著。在奶牛的亚临床酮症中，脂质和脂蛋白代谢异常表现为高甘油三酯血症和高脂蛋白血症，伴极低密度脂蛋白，低密度脂蛋白增加，极高密度脂蛋白减少。β-脂蛋白水平和脂蛋白组分的类似变化证实了这一点，这是脂肪动员综合征第一阶段的特异性变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice VETERINARY SCIENCES-

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： "Medycyna Weterynaryjna" publishes various types of articles which are grouped in the following editorial categories: reviews, original studies, scientific and professional problems, the history of veterinary medicine, posthumous memoirs, as well as chronicles that briefly relate scientific advances and developments in the veterinary profession and medicine. The most important are the first two categories, which are published with short summaries in English. Moreover, from 2001 the editors of "Medycyna Weterynaryjna", bearing in mind market demands, has also started publishing entire works in English. Since 2008 the periodical has appeared in an electronic version. The following are available in this version: summaries of studies published from 1999 to 2005, full versions of all the studies published in the years 2006-2011 (in pdf files), and full versions of the English studies published in the current year (pdf). Only summaries of the remaining studies from the current year are available. In accordance with the principles accepted by the editors, the full versions of these texts will not be made available until next year. All articles are evaluated twice by leading Polish scientists and professionals before they are considered for publication. For years now "Medycyna Weterynaryjna" has maintained a high standard thanks to this system. The review articles are actually succinct monographs dealing with specific scientific and professional problems that are based on the most recent findings. Original works have a particular value, since they present research carried out in Polish and international scientific centers.