Prototype of a Coupling Device to Investigate Focused Ultrasound-Induced Inertial Cavitation for Drug Delivery Applications

Q4 Engineering

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI:10.1515/cdbme-2023-1041

Benedikt George, Michel Wittenbrink, Stefan J. Rupitsch, Ula Savšek, Christian Kroh, Dagmar Fischer, Helmut Ermert

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引用次数: 0

Abstract

Abstract Focused ultrasound (FUS) can be used as a drug delivery application for localized chemotherapy to treat cancer. The effect of ultrasound-induced inertial cavitation is promising to trigger drug release from nanocarriers. To investigate this effect, usually, a passive cavitation detection setup is employed. However, applying such a setup is challenging for in vivo experiments, as the test object may need to be fixed inside the water tank. Thus, we present a prototype of a coupling device that could significantly simplify experiments. Since this setup favors undesired sound wave interference and their resulting exceedance of the Mechanical Index, we additionally investigated different signal lengths. The occurrence of standing waves at a signal length of 44 cycles can both be derived from a changing cavitation activity and our calculations. The appearing interference also results in a mean increase of the cavitation activity by ≈ 5.1 %, verified by our experiments as well.

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研究聚焦超声诱导的惯性空化用于药物输送应用的耦合装置原型

聚焦超声(Focused ultrasound, FUS)可作为一种给药手段应用于肿瘤的局部化疗。超声诱导的惯性空化效应有望引发药物从纳米载体中释放。为了研究这种效应，通常采用被动空化检测装置。然而，在体内实验中应用这种设置是具有挑战性的，因为测试对象可能需要固定在水箱内。因此，我们提出了一个耦合装置的原型，可以显着简化实验。由于这种设置有利于不希望的声波干扰及其导致的机械指数超出，我们还研究了不同的信号长度。在信号长度为44个周期时，驻波的发生可以由空化活动的变化和我们的计算得出。干扰的出现也使空化活度平均提高了约5.1%，实验结果也证实了这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Directions in Biomedical Engineering Engineering-Biomedical Engineering

CiteScore

0.90

自引率

0.00%

发文量

239

审稿时长

14 weeks