Inkjet printability of Celecoxib drug solutions

Q4 Engineering
Ahmed Sannan, Robert Mau, Hermann Seitz, Thomas Eickner, Michael Teske, Niels Grabow
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引用次数: 0

Abstract

Abstract Inkjet printing is a versatile tool for the precise positioning of droplets that is used in many application areas such as 3D printing, biotechnology or pharmacy. This work focused on comparing the inkjet printability of different drug solutions of celecoxib (CLX), a non-steroidal anti-inflammatory drug, to produce drug depots in medical implants. CLX was dissolved in dimethyl sulfoxide (DMSO), poly(ethylene glycol) diacrylate (PEGDA) and a mixture of DMSO and PEGDA in a ratio of 1:1. The pure solvents and the drug solutions were inkjet printed using a Nanoplotter 2.1 with the NanoTip J printhead (GeSiM mbH, Radeberg, Germany). The voltage was varied from 60 V to 150 V using a step size of 5 V. Droplet volume and the trajectory of the droplets were investigated. For DMSO, DMSO-CLX, DMSO-PEGDA and DMSOPEGDA- CLX, reproducible droplet formation occurred with a droplet volume of approximately 300 pl - 500 pl and not more than one satellite droplet in a voltage range between 60 V to 80 V. Inkjet printing of PEGDA and PEGDA-CLX was not reproducible in the range of 60 V to 150 V. DMSO, DMSOPEGDA, DMSO-CLX and DMSO-PEGDA-CLX showed a high inkjet printability. In contrast, inkjet printability of PEGDA and PEGDA-CLX was very limited.
塞来昔布药物溶液的喷墨印刷性能
摘要喷墨打印是一种多功能的工具,用于液滴的精确定位,用于许多应用领域,如3D打印,生物技术或制药。本研究的重点是比较塞来昔布(一种非甾体抗炎药)不同药物溶液在医用植入物中生产药库的喷墨可打印性。CLX溶解在二甲亚砜(DMSO)、聚乙二醇二丙烯酸酯(PEGDA)和DMSO和PEGDA的混合物中,比例为1:1。使用NanoTip J打印头(GeSiM mbH, Radeberg,德国)的nano绘图仪2.1对纯溶剂和药物溶液进行喷墨打印。使用5 V的步长将电压从60 V变化到150 V。研究了液滴的体积和运动轨迹。对于DMSO, DMSO-CLX, DMSO- pegda和DMSOPEGDA- CLX,在60 V至80 V的电压范围内,可重复形成的液滴体积约为300 pl - 500 pl,不超过一个卫星液滴。PEGDA和PEGDA- clx的喷墨打印在60 ~ 150 V范围内是不可复制的。DMSO、DMSOPEGDA、DMSO- clx和DMSO- pegda - clx表现出较高的喷墨打印适性。相比之下,PEGDA和PEGDA- clx的喷墨打印能力非常有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Directions in Biomedical Engineering
Current Directions in Biomedical Engineering Engineering-Biomedical Engineering
CiteScore
0.90
自引率
0.00%
发文量
239
审稿时长
14 weeks
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