Risk of Allergic Rhinitis in Patients with Inflammatory Bowel Disease

IF 2.5 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2023-11-01 DOI:10.15586/v51i6.943

Lun Cai, Jie Liu, Rongrong Yang, Liping Wei, Huazheng Luo, Xiongbin Gui

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引用次数: 0

Abstract

BACKGROUND Numerous parallels exist between inflammatory bowel disease (IBD) and allergic rhinitis (AR), which include risk factors (such as environmental and genetic factors), pathogenesis (immune disorders, epithelial cell barriers, etc.), and treatment (immunosuppressants and immunomodulators, such as cyclosporine and steroids). However, the risk of AR in IBD patients is unknown. OBJECTIVE In this systematic review and meta-analysis, patients with IBD are examined for their risk of AR. METHODS Several databases are accessible in both Chinese and English, including PubMed, BioRXiv, WanFang, the China National Knowledge Infrastructure (CNKI), Web of Science, METSTR, and MedRxiv. Findings presented at allergy, rhinology, thoracic, and gastrointestinal conferences were analyzed. Based on the inclusion and exclusion criteria, two evaluators independently retrieved data, read the literature, and evaluated bias risk. The data analysis was conducted using RevMan 5.4. Case-control and cohort studies were eligible study designs for this research. RESULTS There were 10 case-control studies and 1 cohort study included in the meta-analysis. The experimental group consisted of 65,687 IBD patients, of whom 5838 had AR. A total of 345,176 participants without IBD were included in the control group, of whom 24,625 developed AR. The outcomes demonstrated that IBD patients had a higher risk of developing AR (odds ratio [OR] = 1.48, 95% confidence interval [CI] [1.12, 1.95], Z = 2.78, P = 0.005) than those without IBD. CONCLUSION The risk of AR is higher in IBD patients. Further investigation is required to determine the mechanism behind the association between AR and IBD.

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炎症性肠病患者变应性鼻炎的风险

背景:炎症性肠病(IBD)和变应性鼻炎(AR)之间存在许多相似之处，包括危险因素(如环境和遗传因素)、发病机制(免疫紊乱、上皮细胞屏障等)和治疗(免疫抑制剂和免疫调节剂，如环孢素和类固醇)。然而，IBD患者发生AR的风险尚不清楚。目的:在本系统综述和荟萃分析中，研究IBD患者发生ar的风险。方法:包括PubMed、BioRXiv、万方、中国知网(CNKI)、Web of Science、METSTR和MedRxiv等数据库。在变态反应学、鼻科学、胸外科和胃肠道会议上发表的研究结果进行了分析。根据纳入和排除标准，两位评价员独立检索数据，阅读文献，评估偏倚风险。使用RevMan 5.4软件进行数据分析。病例对照和队列研究是本研究的符合条件的研究设计。结果:meta分析纳入10项病例对照研究和1项队列研究。实验组共65687例IBD患者，其中5838例发生AR，对照组共345,176例无IBD患者，其中24,625例发生AR。结果显示，IBD患者发生AR的风险高于无IBD患者(优势比[OR] = 1.48, 95%可信区间[CI] [1.12, 1.95]， Z = 2.78, P = 0.005)。结论:IBD患者发生AR的风险较高。需要进一步的研究来确定AR和IBD之间关联的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.