Ellagic acid for oral mucositis: investigation of the therapeutic effect in rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-05 DOI:10.1080/13102818.2023.2255688

Ezgi Eroğlu Çakmakoğlu, Adalet Çelebi, Muhammet Bahaeddin Dörtbudak, Hayati Yüksel, Aydın Keskinruzgar

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Abstract

The aim of this study was to evaluate the effect of ellagic acid on 5-fluorouracil-induced oral mucositis in rats. Twenty-four 6-month-old male Wistar albino rats were used. The rats were divided into three groups: Experimental Group I, Experimental Group II and Control Group. A superficial scratch was made on the mucosa of the right cheek pouch on the 3rd day and the 5th day. Oral mucositis protocol was applied to the Control Group. Ellagic acid was administered by gavage to the Experimental Group I from the 1st day to the 5th day along with the 5-FU procedure, and to the Experimental Group II from the 5th day to the 10th day. On the 11th day, all rats were sacrificed. The effect of ellagic acid on the healing of oral mucositis was evaluated histopathologically and immunohistochemically. TNF-α expression was observed at various intensities in the infected incision sites of the Experimental Group I sample, especially in the interstitial area in the lamina propria and mostly in the cytoplasm of the inflammatory cells within the vessel. Similar to the Experimental Group I, TNF-α expression of varying intensity occurred in the inflammatory cells in the Experimental Group II, partly in the epithelium and mostly in the inflammatory cells in the lamina propria. Additional research is needed to elucidate the pathogenic inflammatory mechanisms involved in the mucositis site and the prophylactic and therapeutic roles of antioxidants in the healing of oral mucositis by ellagic acid.

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鞣花酸对口腔黏膜炎大鼠的疗效观察

本研究旨在探讨鞣花酸对5-氟尿嘧啶致大鼠口腔黏膜炎的影响。选用24只6月龄雄性Wistar白化大鼠。将大鼠分为实验一组、实验二组和对照组。第3天、第5天对右颊袋黏膜进行浅表抓痕。对照组采用口腔黏膜炎治疗方案。实验1组于第1 ~ 5天按5-FU法灌胃给药，实验2组于第5 ~ 10天灌胃给药。第11天，处死所有大鼠。采用组织病理学和免疫组织化学方法观察鞣花酸对口腔黏膜炎愈合的影响。实验1组感染切口部位有不同强度的TNF-α表达，特别是在固有层间质区，主要在血管内炎症细胞的细胞质中表达。与实验1组相似，实验2组炎症细胞中出现不同程度的TNF-α表达，部分表达于上皮，大部分表达于固有层炎症细胞。需要进一步的研究来阐明粘膜炎部位的致病炎症机制，以及抗氧化剂在鞣花酸愈合口腔粘膜炎中的预防和治疗作用。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.