Determinants of serum cytokines in a population sample of healthy subjects from Iran

Seyed Reza Mirhafez, Ahmadreza Zarifian, Ali Movahedi, Gordon A. Ferns, Thozhukat Sathyapalan, Majid Ghayour-Mobarhan, Amirhossein Sahebkar
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Abstract

Introduction Cytokines are synthesized and released by immune system cells and mediate critical immune responses. Aging is associated with increased serum levels of some pro-inflammatory cytokines . A positive correlation between the concentration of several cytokines and blood pressure has been reported; higher cytokine concentrations may be related to the underlying causes of hypertension through the effects of inflammatory responses or as an independent etiology for hypertension .To assess the relationship between the serum levels of inflammatory cytokines and growth factors, with biochemical and anthropometric characteristics in healthy Iranian subjects. Material and methods Anthropometric measurements and blood sampling were performed in 103 healthy Iranian participants. Fasting blood glucose (FBG), hs-CRP and lipid profile were measured in these participants. 12 serum cytokines/growth factors (MCP-1, TNF-α, EGF, IFN-γ, VEGF, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10 were measured. Results FBG was positively associated with serum IL-2, IL-4 and IL-1α (P = 0.044, < 0.001 and = 0.017, respectively). Serum EGF and IL-4 were positively associated with age (P < 0.001). IL-8 was inversely associated with SBP (P = 0.002) and gender (P = 0.028). There was a positive association between VEGF and HDL (P = 0.007). The serum levels of IFN-γ and TNF-α were positively associated with serum TG (P = 0.018 and 0.006, respectively). Conclusions There are associations between various pro-and anti-inflammatory cytokines in serum and several anthropometric measurements.
伊朗健康人群样本中血清细胞因子的决定因素
细胞因子是由免疫系统细胞合成和释放,介导关键的免疫反应。衰老与一些促炎细胞因子的血清水平升高有关。一些细胞因子的浓度与血压有正相关的报道;较高的细胞因子浓度可能通过炎症反应的影响与高血压的潜在原因有关,或作为高血压的独立病因。评估伊朗健康受试者血清中炎症因子和生长因子水平与生化和人体测量特征之间的关系。材料和方法对103名健康的伊朗参与者进行了人体测量和血液取样。在这些参与者中测量空腹血糖(FBG)、hs-CRP和脂质谱。检测血清12种细胞因子/生长因子(MCP-1、TNF-α、EGF、IFN-γ、VEGF、IL-1α、IL-1β、IL-2、IL-4、IL-6、IL-8和IL-10)。结果FBG与血清IL-2、IL-4、IL-1α呈正相关(P = 0.044, <0.001和= 0.017)。血清EGF、IL-4与年龄呈正相关(P <0.001)。IL-8与收缩压(P = 0.002)和性别(P = 0.028)呈负相关。VEGF与HDL呈正相关(P = 0.007)。血清中IFN-γ和TNF-α水平与血清TG呈显著正相关(P分别为0.018和0.006)。结论血清中各种促炎和抗炎细胞因子与多项人体测量指标存在相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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