Efficacy of ultrasound-guided subacromial bursa steroid injection for treating shoulder pain in post-stroke hemiparetic patients

IF 0.6 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Sunbin Chen, Shibin Lin, Minghui Li, Siwei Li, Kefeng Yang
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Abstract

Purpose: To assess the efficacy of ultrasound-guided subacromial bursa (SAB) steroid injection for treating hemiplegic shoulder pain (HSP) after stroke (CS), as well as its impact on joint mobility, and inflammatory mediators.Methods: Seventy-two (72) patients with CS-related HSP were divided into two groups: study and control groups. The study group received ultrasound-guided SAB injection of triamcinolone acetonide in addition to conventional treatment, while control group received only conventional rehabilitation. Both groups received 4 weeks of treatment and were assessed using pain visual analogue scale (VAS) and passive range of motion (PROM) indices before treatment and at 1, 4, and 12 weeks after treatment. Additionally, the Fugl-Meyer motor function (FMA-U) scale score, activities of daily living (ADL) score, modified Barthel index (MBI), serum IL-1β, IL-6, nitric oxide (NO) levels, and incidence of adverse reactions were assessed before and after 4 weeks of treatment.Results: The study group had a significantly higher total efficacy/effectiveness (86.11 %) compared to control group (53.89 %). Both groups showed initial decreases and subsequent increases in VAS and PROM from week 1 to week 12 after treatment. However, the study group had significantly lower VAS scores, angle of forward flexion, abduction, and external rotation at all time points compared to control group (p < 0.05). At week 4, the study group had significantly higher FMA-U, ADL, and MBI scores, as well as significantly lower IL-1β, IL-6, and NO levels when compared to control group (p < 0.05).Conclusion: Ultrasound-guided SAB steroid injection improves the efficacy of HSP after CS, improves joint mobility, and reduces serum levels of IL-1β, IL-6, and NO. Further large-sample studies with increased sample sizes and longer investigation periods are needed to validate these findings.
超声引导肩峰下囊类固醇注射治疗脑卒中后偏瘫患者肩痛的疗效观察
目的:评价超声引导下肩峰下囊(SAB)类固醇注射治疗脑卒中后偏瘫性肩痛(HSP)的疗效,以及对关节活动能力和炎症介质的影响。方法:将72例cs相关性热休克患者分为研究组和对照组。研究组在常规治疗的基础上给予超声引导下SAB注射曲安奈德,对照组仅给予常规康复治疗。两组均接受治疗4周,分别于治疗前、治疗后1周、4周和12周采用疼痛视觉模拟评分(VAS)和被动活动范围(PROM)指数进行评估。观察治疗前后Fugl-Meyer运动功能(FMA-U)评分、日常生活能力(ADL)评分、改良Barthel指数(MBI)、血清IL-1β、IL-6、一氧化氮(NO)水平及不良反应发生率。结果:研究组总有效率(86.11%)显著高于对照组(53.89%)。治疗后第1周至第12周,两组VAS和PROM均呈现先降低后升高的趋势。然而,与对照组相比,研究组在所有时间点的VAS评分、前屈角度、外展角度和外旋角度均显著降低(p <0.05)。在第4周,研究组的FMA-U、ADL和MBI评分显著高于对照组,IL-1β、IL-6和NO水平显著低于对照组(p <0.05)。结论:超声引导下注射SAB类固醇可提高CS后HSP的疗效,改善关节活动性,降低血清IL-1β、IL-6、NO水平。进一步的大样本研究需要增加样本量和更长的调查时间来验证这些发现。
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来源期刊
CiteScore
1.00
自引率
33.30%
发文量
490
审稿时长
4-8 weeks
期刊介绍: We seek to encourage pharmaceutical and allied research of tropical and international relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and the healthcare professionals. We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). Although primarily devoted to original research papers, we welcome reviews on current topics of special interest and relevance.
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