Green synthesis of biocompatible Gd3+-doped ultrasmall carbon-based nanohybrids from coffee wastes

IF 6.4 3区环境科学与生态学 Q2 ENERGY & FUELS

Carbon Resources Conversion Pub Date : 2023-09-11 DOI:10.1016/j.crcon.2023.09.001

Konstantin Paliienko , Anna Topchylo , Sergei Alekseev , Alain Géloën , Yurii Milovanov , Tetiana Lysenko , Valeriy Skryshevsky , Tatiana Borisova , Vladimir Lysenko

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Abstract

A cheap method allowing fabrication of biocompatible, ultra-small (2–10 nm) and fluorescent (λ_em = 425–500 nm) nanohybrids (NHs) from coffee wastes is reported. The gadolinium-doped nanohybrids (GDNHs) or gadolinium-free carbon dots (GFCDs) can be synthesized in a domestic microwave oven according to green synthesis principles. Hydrodynamic sizes, chemical composition, impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and compared. In particular, doping of the NHs with Gd³⁺ ions, up to 1.87 % w/w of gadolinium per particles’ weight, will allow their application for magnetic resonance imaging (MRI). Furthermore, cell culture tests on human adenocarcinomic alveolar basal epithelial cells line (A549) have shown high biocompatibility of the GDNHs and in a wide concentration range 100–1000 µg/ml.

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利用咖啡废料绿色合成具有生物相容性的掺杂 Gd3+ 的超小型碳基纳米混合物

报告采用一种廉价的方法，利用咖啡废料制造出生物相容性好、超小型（2-10 nm）且具有荧光（λem = 425-500 nm）的纳米杂化物（NHs）。根据绿色合成原理，掺钆纳米杂化物（GDNHs）或无钆碳点（GFCDs）可在家用微波炉中合成。研究人员对 GDNHs 和 GFCDs 的流体力学尺寸、化学成分、对质子磁共振弛豫时间和光学特性的影响进行了详细研究和比较。特别是，在 NHs 中掺入 Gd3+ 离子（每颗粒重量中的钆含量高达 1.87 % w/w）将使其能够应用于磁共振成像（MRI）。此外，对人类腺癌肺泡基底上皮细胞系（A549）进行的细胞培养测试表明，GDNHs 具有很高的生物相容性，浓度范围为 100-1000 µg/ml。

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来源期刊

Carbon Resources Conversion Materials Science-Materials Science (miscellaneous)

CiteScore

9.90

自引率

11.70%

发文量

审稿时长

10 weeks

期刊介绍： Carbon Resources Conversion (CRC) publishes fundamental studies and industrial developments regarding relevant technologies aiming for the clean, efficient, value-added, and low-carbon utilization of carbon-containing resources as fuel for energy and as feedstock for materials or chemicals from, for example, fossil fuels, biomass, syngas, CO2, hydrocarbons, and organic wastes via physical, thermal, chemical, biological, and other technical methods. CRC also publishes scientific and engineering studies on resource characterization and pretreatment, carbon material innovation and production, clean technologies related to carbon resource conversion and utilization, and various process-supporting technologies, including on-line or off-line measurement and monitoring, modeling, simulations focused on safe and efficient process operation and control, and process and equipment optimization.