A novel dual stimuli-responsive and double-loaded insecticidal nanoformulation for efficient control of insect pest

IF 13.2 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2023-10-01 DOI:10.1016/j.cej.2023.146012

Kan Wang, Yan Wang, Yuanyuan Wu, Jianjun Jiang, Yixi Zhang, Na Yu, Zewen Liu

{"title":"A novel dual stimuli-responsive and double-loaded insecticidal nanoformulation for efficient control of insect pest","authors":"Kan Wang, Yan Wang, Yuanyuan Wu, Jianjun Jiang, Yixi Zhang, Na Yu, Zewen Liu","doi":"10.1016/j.cej.2023.146012","DOIUrl":null,"url":null,"abstract":"The dual stimuli-responsive nanoformulations with two insecticides promise to improve insecticidal efficacy, which has yet to be developed for insect pest control. In this study, glutathione (GSH)/pH dual stimuli-responsive and chlorantraniliprole (CHL)/spinosad (SPI) double-loaded nanoformulations (DMSNs-CHL-polyethyleneimine (PEI)-SPI) are designed to manage Spodoptera frugiperda. The dendritic mesoporous silica nanoparticles (DMSNs)-based DMSNs-CHL-PEI-SPI exhibit a high insecticide loading content (52.03%), strong corn leave adhesion (87.63%), and enhanced insecticide release behaviors (94.53% for CHL and 57.05% for SPI at 144 h) in response to GSH and alkaline conditions. DMSNs-CHL-PEI-SPI can effectively enhance the utilization efficiency of insecticides for the dual stimuli-responsive. Bioactivity tests showed that the corn leaves sprayed with DMSNs-CHL-PEI-SPI possess higher toxicity to Spodoptera frugiperda than physical mixture and single-loaded nanoformulations with the same amount of active ingredients. DMSNs-CHL-PEI-SPI also possesses a long-term control efficacy, with ∼ 20% pest mortality on corn leaves at 21 d after spraying. In fields, two or more insecticides are usually used to control one insect pest, instead of a single active ingredient. That means the double-loaded insecticide nanoformulation is a practical tool for developing novel insecticide formulations. These results reveal that the dual stimuli-responsive and double-loaded insecticidal nanoformulations are highly promising for sustainable management of insect pests.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"27 1","pages":"0"},"PeriodicalIF":13.2000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cej.2023.146012","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}

引用次数: 1

Abstract

The dual stimuli-responsive nanoformulations with two insecticides promise to improve insecticidal efficacy, which has yet to be developed for insect pest control. In this study, glutathione (GSH)/pH dual stimuli-responsive and chlorantraniliprole (CHL)/spinosad (SPI) double-loaded nanoformulations (DMSNs-CHL-polyethyleneimine (PEI)-SPI) are designed to manage Spodoptera frugiperda. The dendritic mesoporous silica nanoparticles (DMSNs)-based DMSNs-CHL-PEI-SPI exhibit a high insecticide loading content (52.03%), strong corn leave adhesion (87.63%), and enhanced insecticide release behaviors (94.53% for CHL and 57.05% for SPI at 144 h) in response to GSH and alkaline conditions. DMSNs-CHL-PEI-SPI can effectively enhance the utilization efficiency of insecticides for the dual stimuli-responsive. Bioactivity tests showed that the corn leaves sprayed with DMSNs-CHL-PEI-SPI possess higher toxicity to Spodoptera frugiperda than physical mixture and single-loaded nanoformulations with the same amount of active ingredients. DMSNs-CHL-PEI-SPI also possesses a long-term control efficacy, with ∼ 20% pest mortality on corn leaves at 21 d after spraying. In fields, two or more insecticides are usually used to control one insect pest, instead of a single active ingredient. That means the double-loaded insecticide nanoformulation is a practical tool for developing novel insecticide formulations. These results reveal that the dual stimuli-responsive and double-loaded insecticidal nanoformulations are highly promising for sustainable management of insect pests.

查看原文本刊更多论文

一种新型的双刺激响应和双负载杀虫纳米制剂，用于有效控制害虫

含有两种杀虫剂的双重刺激反应纳米制剂有望提高杀虫效果，这在害虫防治方面还有待开发。本研究设计了谷胱甘肽(GSH)/pH双刺激响应型和氯氨酰胺(CHL)/spinosad (SPI)双负载纳米制剂(dmsn -CHL-聚乙烯亚胺(PEI)-SPI)来管理frugiperda。枝状介孔二氧化硅纳米颗粒(dmsn -CHL- pei -SPI)在GSH和碱性条件下表现出高的杀虫剂负载含量(52.03%)、强的玉米叶片粘附性(87.63%)和增强的杀虫剂释放行为(144 h时CHL释放率为94.53%，SPI释放率为57.05%)。dmsn - chl - pei - spi可有效提高杀虫剂对双刺激响应的利用效率。生物活性试验表明，dmsn - chl - pei - spi喷施玉米叶片对夜蛾的毒力高于物理混合剂和相同活性成分用量的单负载纳米制剂。dmsn - chl - pei - spi还具有长期防治效果，在喷洒后21 d对玉米叶片的害虫死亡率为20% ~ 20%。在田间，通常使用两种或两种以上的杀虫剂来控制一种害虫，而不是使用一种有效成分。这意味着双重负载的纳米杀虫剂配方是开发新型杀虫剂配方的实用工具。这些结果表明，双重刺激响应和双重负载的杀虫纳米制剂在害虫的可持续管理中具有很大的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.