Histological examination of biopsy material of animal bone tissue using osteoplastic biocomposite coating of implants accelerating consolidation

Abstract

In modern veterinary and humane medicine, the issue of optimizing reparative osteogenesis, aimed at accelerating consolidation, preventing bacterial infection, a stabilization method, as well as activating osteoinductive and osteoconductive properties, is quite acute. This can be achieved using osteoplastic biocomposite coatings on implants. The significant role of such components as hydroxyapatite, methyluracil, amoxicillin in metabolic processes aimed at regenerative, antibacterial and metabolic processes of osteogenesis has been determined. The group of authors set the goal of the study: to study, using a histological method, the quantitative and qualitative aspects of fusion of a fracture of the middle third of the diaphysis of long tubular bones (radius), in an experiment, using the developed biocomposite coating. The material for this study was histotopographic preparations of bone regenerates obtained on day 35 using a needle for trephine biopsy of bone tissue, after consolidation of the simulated fracture was established using implants with the developed osteoplastic coating. As a result of the study of histotopographic materials using 3.5% and 5% biocomposite coating to accelerate consolidation, in the experimental groups there is no amount of the developed composite, which indicates biocompatibility with complete biointegration without allergenic and cytostatic effects.Throughout the experiment, no significant difference was found between the experimental groups; in each group, restored microcirculation was visualized with many physiological Haversian canals with blood vessels, the nervous system and adequate tissue trophism. Histological examination of the formed bone regenerate is necessary to confirm the completed accelerated process of osteogenesis in small non-productive animals.