CFD Study on Hemodynamic Characteristics of Inferior Vena Cava Filter Affected by Blood Vessel Diameter

Q4 Biochemistry, Genetics and Molecular Biology

Molecular & Cellular Biomechanics Pub Date : 2023-01-01 DOI:10.32604/mcb.2023.044445

Shiyue Zhang, Xue Song, Jingying Wang, Wen Huang, Yue Zhou, Mingrui Li

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引用次数: 0

Abstract

Pulmonary embolism (PE), caused by deep venous thrombosis (DVT), is a disease with high morbidity and mortality. Implantation of inferior vena cava filters is an important method for the clinical prevention of PE. The hemodynamic characteristics of filters implanted in the inferior vena cava (IVC) have a significant impact on their performance. However, IVC diameters vary among patients. This may have a direct impact on the hemodynamic properties of the filter. At present, there is no research on this kind of problem to be investigated. In this paper, the hemodynamic properties of the VenaTech convertible filter were simulated in three different IVC models of 15, 20 and 25 mm diameters, using computational fluid dynamics (CFD) as a control variable (only the IVC diameter is varied). The results showed that the diameter has a significant impact on the hemodynamic characteristics after filter implantation. The IVC diameter has a great influence on the stagnation zone of the blood flow, the maximum wall shear stress (WSS) on the upstream side along the filter wire, and the flow resistance. The case of 15 mm diameter was the most prone to thrombus formation downstream of the filter head in the IVC, but the larger WSS on the upstream along the filter wire may facilitate thrombus lysis. Therefore, the change in vessel diameter should be considered when performing filter implantation for patients.

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下腔静脉过滤器血流动力学特性受血管直径影响的CFD研究

肺动脉栓塞(PE)是由深静脉血栓形成(DVT)引起的一种高发病率和死亡率的疾病。下腔静脉滤器植入术是临床预防PE的重要方法。植入下腔静脉的滤嘴的血流动力学特性对滤嘴的性能有重要影响。然而，不同患者的下腔静脉直径不同。这可能对过滤器的血流动力学特性有直接影响。目前，还没有关于这类问题的研究。本文采用计算流体动力学(CFD)作为控制变量(仅改变内腔直径)，在直径为15、20和25 mm的三种不同的内腔模型中模拟了VenaTech可转换过滤器的血流动力学特性。结果表明，滤嘴直径对滤嘴植入后的血流动力学特性有显著影响。下腔静脉直径对血流停滞区、沿滤丝上游最大壁面剪切应力(WSS)和流动阻力有较大影响。直径为15mm的情况下，下腔静脉滤头下游最容易形成血栓，但沿滤丝上游较大的WSS可能有利于血栓溶解。因此，在对患者进行滤镜植入时，应考虑血管直径的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular & Cellular Biomechanics CELL BIOLOGYENGINEERING, BIOMEDICAL&-ENGINEERING, BIOMEDICAL

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications.