SETD2 Deficiency Promotes Inflammatory Bowel Disease via Oxidative Stress and FasL-Mediated Apoptosis

Abstract

Background: SET-domain-containing 2 (SETD2) is known as the only trimethyltransferase for regulating histone H3 lysine 36 (H3K36) methylation, being involved in the generation and development of many diseases. Although SETD2 has been found to modulate oxidative stress in the intestinal epithelial tissue of inflammatory bowel disease (IBD) samples, the specific functions of SETD2 in IBD development are yet to be fully understood.