Acetylsalicylic acid inhibits platelet PAI-1 antigen release without affecting circulating PAI-1 antigen in plasma.

A Cogo, E Ling, A Sturk, J W ten Cate, P Prandoni
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引用次数: 8

Abstract

An important plasminogen activator-inhibitor (PAI-1) is present in plasma and concentrated in alpha-granules of platelets. PAI-1 is released during platelet stimulation in vitro. It is presently unknown to what extent the treatment with acetylsalicylic acid (ASA) inhibits platelet PAI-1 release and if release inhibition has an effect on plasma PAI-1 levels. We therefore investigated by a double-blind placebo-controlled crossover study the effects of oral ASA (500 mg/day for 3 days) on platelet PAI-1 release and on plasma PAI-1 levels of healthy male volunteers. The PAI-1 release from platelets stimulated by arachidonic acid and collagen was significantly reduced by ASA: from average values of 88 and 80% to 14 and 17%, respectively (p less than 0.01). However, plasma PAI-1 levels were not modified by this treatment. We can conclude that platelet PAI-1 release does not play a role in modulating the plasma PAI-1 levels in healthy volunteers.

乙酰水杨酸抑制血小板PAI-1抗原释放,不影响血浆循环PAI-1抗原。
一种重要的纤溶酶原激活抑制剂(PAI-1)存在于血浆中,并集中于血小板α颗粒中。PAI-1在体外刺激血小板过程中释放。目前尚不清楚乙酰水杨酸(ASA)治疗在多大程度上抑制血小板PAI-1释放,以及释放抑制是否对血浆PAI-1水平有影响。因此,我们通过一项双盲安慰剂对照交叉研究调查了口服ASA (500 mg/天,连续3天)对健康男性志愿者血小板PAI-1释放和血浆PAI-1水平的影响。花生四烯酸和胶原刺激的血小板PAI-1释放量显著降低,分别从平均值88%和80%降至14%和17% (p < 0.01)。然而,这种治疗并未改变血浆PAI-1水平。我们可以得出结论,血小板PAI-1释放在健康志愿者血浆PAI-1水平的调节中不起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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