Effects of The Combination of Seluang Fish (Rasbora spp.) and Pasak Bumi (Eurycoma Longifolia Jack) on Systemic Inflammation and Neurotransmitter in Stunting Model Rat (Rattus Novergicus)

Magna Medica Pub Date : 2023-02-01 DOI:10.26714/magnamed.10.1.2023.27-39

Didik Dwi Sanyoto, Hendra Nur'amin, Triawanti Triawanti, Dimas Ikhsan Airlangga, Gastin Gabriel Jangkang

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Abstract

Background: Stunting causes growth and development issues which are characterized by a systemic inflammatory response and neurotransmitter disorder. The South Kalimantan natural resources i.e. extracts of Pasak Bumi (Eurycoma longifolia Jack) and seluang fish have the potential as a modified therapy for stunting management.Objective: To analyze the effect of Pasak Bumi and seluang fish administration in overcoming systemic inflammation and neurotransmitter disorders in the stunting rats model.Methods: Rats were divided into six group i.e Positive Control (KP): Stunting rats + placebo + standard feed; (P1): stunting rats + 70% EPB 15 mg/kg body weight (BW) + standard feed; (P2): Stunting rats + DHA 1 mg/kg BW + standard feed; (P3): Stunting rats + EPB 15 mg/kg BW + DHA 1 mg/kg BW + standard feed; (P4): Stunting rats + seluang fish; (P5): Stunting rats + EPB 15 mg/kg BW + seluang fish for 5 weeks; Parameters measured were levels of IL-6, TNF-α, and serotonin.Results: There were significant differences in levels of TNF-α (p = 0.000) and serotonin (p = 0.000).Conclusion: The administration of Pasak Bumi extract and seluang fish was able to inhibit systemic inflammation and neurotransmitter dysregulation.

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色梁鱼与长叶Eurycoma Longifolia Jack联合使用对发育迟缓模型大鼠(Rattus Novergicus)全身炎症和神经递质的影响

背景:发育迟缓导致生长发育问题，其特征是全身炎症反应和神经递质紊乱。南加里曼丹的自然资源，即Pasak Bumi (Eurycoma longifolia Jack)和seluang鱼的提取物，具有作为发育迟缓管理改良疗法的潜力。目的:分析巴沙布米和色黄鱼对发育迟缓大鼠模型全身炎症和神经递质紊乱的影响。方法:将大鼠分为阳性对照组(KP):发育迟缓大鼠+安慰剂+标准饲料组;(P1):发育迟缓大鼠+ 70% EPB 15 mg/kg体重(BW) +标准饲料;(P2):发育迟缓大鼠+ DHA 1mg /kg BW +标准饲料;(P3):发育迟缓大鼠+ EPB 15 mg/kg BW + DHA 1 mg/kg BW +标准饲料;(P4):发育不良大鼠+色銮鱼;(P5):发育迟缓大鼠+ EPB 15 mg/kg BW +色黄鱼5周;测量的参数是IL-6、TNF-α和血清素水平。结果:两组间TNF-α (p = 0.000)、血清素(p = 0.000)水平差异有统计学意义。结论:巴沙布米提取物和色黄鱼对全身炎症和神经递质失调具有抑制作用。

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Magna Medica

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