Effectiveness of Bitter melon (Momordica charantia L) Extract on Growth of Trichopyton rubrum: In Vitro Study

Magna Medica Pub Date : 2023-02-01 DOI:10.26714/magnamed.10.1.2023.19-26

Vika Pangesty, Ika Dyah Kurniati, Kanti Ratnaningrum

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Abstract

Trichophyton rubrum is type of fungus that most often causes superficial fungal infections. Development of herbal ingredients as antifungal therapy is carried out to find alternative therapies for fungal infections. Bitter melon contains various compounds that have potential to be used as antifungals, including flavonoids and saponins. The aim of this study was to determine the effect of bitter melon extract (Momordica charantia L) on the growth of Trichopyton rubrum. This study used bitter melon extract at concentrations of 5%, 25%, 50%, 75% and 100%. Ketoconazole concentrations of 2% was used as a positive control. Pure cultures of Trichopyton rubrum were diluted using physiological NaCl. Fungal growth was observed microscopically and macroscopically. Results showed that Trichopyton rubrum grew at a concentration of 5% while at concentrations of 25%, 50%, 75% and 100% there was no Trichopyton rubrum growth. Bitter melon extract at a concentration of 25% had similar effect as ketoconazole 2%. Conclusion Bitter melon extract at concentrations of 25%, 50%, 75% and 100% had a similar effect to 2% ketoconazole in inhibiting the growth of Tricophyton rubrum.

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苦瓜(Momordica charantia L)提取物对红毛藓生长的体外研究

红毛癣菌是一种最常引起浅表真菌感染的真菌。开发草药成分作为抗真菌治疗进行寻找替代治疗真菌感染。苦瓜含有多种化合物，包括类黄酮和皂苷，有可能被用作抗真菌剂。本研究旨在探讨苦瓜提取物对红毛癣菌生长的影响。本研究使用浓度为5%、25%、50%、75%和100%的苦瓜提取物。以2%酮康唑浓度为阳性对照。用生理NaCl对红毛癣菌纯培养物进行稀释。显微镜和宏观观察真菌生长情况。结果表明，在浓度为5%时，红毛滴虫生长，而在浓度为25%、50%、75%和100%时，红毛滴虫均未生长。25%浓度的苦瓜提取物与2%浓度的酮康唑效果相近。结论25%、50%、75%和100%浓度的苦瓜提取物对红毛癣菌的抑制作用与2%酮康唑相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Magna Medica

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