Diabetic Wound Healing Activity of Anabas testudineus Fish Scales

Magna Medica Pub Date : 2023-02-01 DOI:10.26714/magnamed.10.1.2023.40-47

Erwin Rosadi, Lia Yulia Budiarti, Bhisma Ridho Romadhon, Nida Nurkhalishah, Nur Salsabila Apriliani Risma Putri, Nur Azmina Aisyah, Isnaini Isnaini

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Abstract

Background: Anabas testudineus fish scales are part of the fish that has not been used optimally. Fish scales contain chitin. Chitin which undergoes deacetylation, produces chitosan. Chitosan is an efficacious compound for antibacterial and diabetic wound healing.Objective: This study aimed to extract chitosan from fish scales and test the diabetic wound healing activity of fish scale extract gelMethods: Extraction of fish scales using 0.3 M NaOH, 0.55 M HCl, and 50% NaOH. FTIR will analyze the extraction results to see the functional groups of the extract. Activity test of fish scale extracts diabetic wound healing gel was carried out on Rattus novergicus Wistar strain for 14 days. There were five treatments: negative control, positive control given octenillinR, and fish scale extract gel conc. 5%, 10%, and 15%.Results: The results showed that the fish scales extract contained chitosan, and gel extract fish scale conc 5% have diabetic wound healing activity better than 10% and 15%. Conclusion: A. testudineus fish scale extract contains chitosan, as seen from the FTIR results.

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泥鳅鱼鳞对糖尿病创面愈合活性的影响

背景:泥鳅鱼鳞是鱼类中尚未得到充分利用的部分。鱼鳞含有几丁质。几丁质经过去乙酰化，产生壳聚糖。壳聚糖是一种有效的抗菌和糖尿病伤口愈合的化合物。目的:从鱼鳞中提取壳聚糖，考察鱼鳞提取物凝胶对糖尿病创面的愈合作用。方法:用0.3 M NaOH、0.55 M HCl、50% NaOH提取鱼鳞。FTIR将分析提取结果，以查看提取物的官能团。对糖尿病创面愈合凝胶鱼鳞提取物对褐家鼠Wistar菌株进行了14 d的活性试验。共设5个处理:阴性对照组、阳性对照组和鱼鳞提取物凝胶对照组。5%， 10%和15%。结果:鱼鳞提取物含壳聚糖，鱼鳞凝胶提取物含壳聚糖5%，其糖尿病创面愈合活性优于10%和15%。结论:从红外光谱分析可以看出，龙蚌鱼鳞提取物中含有壳聚糖。

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Magna Medica

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