Whole complement hemolytic activity (CH50) following infusion of stroma-free and polyhemoglobin solutions in rats.

Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI:10.3109/10731199009117302

J Ning, T M Chang

引用次数: 4

Abstract

We developed a method to determine whole complement hemolytic activity (CH50) in rat plasma using a modification of the method of Mayer(1). Plasma CH50 level in 30 male Sprague Dawley rats was 1000 +/- 200 units. Following infusions with human and rat stroma-free hemoglobin or polyhemoglobin solutions, CH50 did not change significantly in rats when compared to albumin infused rats. On the other hand, CH50 significantly decreased in the group receiving membrane stroma and bacterial endotoxins.

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大鼠灌注无基质和多血红蛋白溶液后的全补体溶血活性(CH50)。

我们开发了一种测定大鼠血浆中全补体溶血活性(CH50)的方法，该方法是对Mayer方法的改进(1)。30只雄性大鼠血浆CH50水平为1000 +/- 200单位。在输注人与大鼠无基质血红蛋白或多血红蛋白溶液后，与输注白蛋白的大鼠相比，大鼠的CH50没有明显变化。另一方面，膜间质和细菌内毒素组CH50显著降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials, artificial cells, and artificial organs

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