Bone resorption markers in the diagnosis of acute destructive mastoiditis

Abstract

It is important to identify an inflammatory destruction of bone tissue in the early stages in acute mastoiditis. In the available medical literature, there is no information on the use of laboratory markers of bone resorption and bone formation for the diagnosis of acute destructive mastoiditis. Objective of the study. To analyze the diagnostic value of serum deoxypyridinoline and osteocalcin levels in biological fluids in acute destructive mastoiditis. Materials and methods. There were 43 patients on treatment, urgently hospitalized with acute mastoiditis diagnosis (Н70.0). The concentration of deoxypyridinoline in the urine and osteocalcin in the blood were determined in all the patients. The biomaterials are taken from the patients on the day of their hospitalization and before their discharge. A score rating system was used to interpret the results of the laboratory study. Results. Analysis of obtained laboratory data has shown a connection between the degree of bone destruction and the levels of the bone resorption markers. The patients with the bone destruction had high titers, especially patients with an inflammation spreading to surrounding topographic areas and with developing intracranial complications. Conclusions. Measuring of levels of markers of bone resorption and bone formation allows optimizing a treatment of patients with an acute mastoiditis on account of early diagnosis of temporal bone destruction, preventing attempts of ineffective conservative treatment, timely determining the indications for surgery with planning of its appropriate volume.