Synthesis, spectral characterization, and biological activities of novel palladium(II) and platinum(II) complexes of active Schiff base ligands

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-09-19 DOI:10.4314/bcse.v37i6.7

Jaswant Raj, Akshita Jain, Naveen Sharma, Anita Kumari, Nighat Fahmi

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引用次数: 0

Abstract

ABSTRACT. A new series of palladium(II) and platinum(II) Schiff base complexes have been synthesized by the interaction of ligands N-(2-fluoro benzylidene)isonicotinohydrazone (L1H) and N-(2-fluorophenylethanone) isonicotinohydrazone (L2H) with PdCl2 and PtCl2. Elemental investigations, melting point determinations, molecular weight determinations, IR, 1H NMR, and UV-Visible spectral studies were used to describe the structure and bonding pattern of ligands and their metal complexes. These analyses revealed that the ligands coordinate with the metal ions in a monobasic bidentate manner and that the complexes have a square planar geometry. The antimicrobial activities of both the ligands and their palladium(II) and platinum(II) complexes have been tested against various bacterial and fungal strains and showed considerable antifungal and antibacterial characteristics. The in vitro cytotoxic activity of [Pt(L2H)]Cl2 complex was assessed by examining its potential to inhibit cell proliferation against the human HeLa cell line(cervical cancer cell line) using MTT assay and the antioxidant activity of [Pt(L1H)2]Cl2 compound was performed against DPPH. The results showed a dose-dependent cytotoxic and radical scavenging activity thus pointing towards the biological significance of Pt(II) complexes. KEY WORDS: Schiff base ligands, Antimicrobial activity, Scavenging activity, Cytotoxic Bull. Chem. Soc. Ethiop. 2023, 37(6), 1383-1396. DOI: https://dx.doi.org/10.4314/bcse.v37i6.7

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新型活性席夫碱配体钯(II)和铂(II)配合物的合成、光谱表征和生物活性

摘要通过配体N-(2-氟苄基)异烟碱腙(L1H)和N-(2-氟苯乙酮)异烟碱腙(L2H)与PdCl2和PtCl2的相互作用，合成了一系列新的钯(II)和铂(II)希夫碱配合物。元素研究、熔点测定、分子量测定、IR、1H NMR和uv -可见光谱研究被用来描述配体及其金属配合物的结构和键合模式。这些分析表明，配体与金属离子以单碱双齿方式配位，配合物具有方形平面几何形状。该配体及其钯(II)和铂(II)配合物对多种细菌和真菌的抑菌活性进行了测试，并显示出相当的抗真菌和抗菌特性。采用MTT法检测[Pt(L2H)]Cl2复合物对人HeLa细胞系(宫颈癌细胞系)的细胞增殖抑制作用，并测定[Pt(L2H)]Cl2复合物对DPPH的抗氧化活性。结果显示，Pt(II)复合物具有剂量依赖性的细胞毒性和自由基清除活性，从而指出Pt(II)复合物的生物学意义。关键词:希夫碱配体;抗菌活性;清除活性;公牛。化学。Soc。中国生物医学工程学报，2017,37(6)，1383-1396。DOI: https://dx.doi.org/10.4314/bcse.v37i6.7

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.