Au@Fe3O4 NANOPARTICLES: PREPARATION, CHARACTERIZATION AND CYTOTOXIC EVALUATION

Azerbajčan himiâ žurnaly Pub Date : 2023-09-19 DOI:10.32737/0005-2531-2023-3-98-104

Z. Kelgenbaeva

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Abstract

Gold-coated iron oxide nanoparticles are a class of potential theranostic nanoparticles that have been studied for their multitude of magnetic and optical properties with possible medical applications. In this work, spherical Au@Fe3O4 nanoparticles were successfully synthesized from Fe electrodes immersed in HAuCl4 solution using a very simple method - pulsed plasma in liquid, without any dopants or special conditions for stabilization. Vibrating sample magnetometer indicated ferromagnetic behavior of the particles at room temperature with coercivity and saturation magnetization of Hc=175 and Ms= 3.56 emu/g, respectively. Face-centered cubic Au and spinel inverse structure of FCC- Fe3O4 were determined by X-Ray diffraction analysis. High-resolution transmission electron microscopic analysis revealed that Fe3O4 particles with 14 nm in size are connected to 18 nm Au particles. The cytotoxicity of the nanoparticles was evaluated using a XTT assay on Hela cells, revealing very low (cell viability: 98-89% with Fe3O4 and 99-91% for Au@Fe3O4 NPs). This indicates that Au improves biocompatibility of magnetic nanoparticles, enabling their application in biomedicine

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Au@Fe3O4纳米颗粒:制备，表征和细胞毒性评价

金涂层氧化铁纳米颗粒是一类潜在的治疗纳米颗粒，因其具有多种磁性和光学特性而被研究，并可能在医学上应用。在本研究中，利用一种非常简单的方法——液体脉冲等离子体，将Fe电极浸泡在HAuCl4溶液中，成功地合成了球形Au@Fe3O4纳米粒子，无需任何掺杂剂或特殊的稳定条件。振动样品磁强计表明，颗粒在室温下具有铁磁性，矫顽力Hc=175，饱和磁化强度Ms= 3.56 emu/g。用x射线衍射法测定了FCC- Fe3O4的面心立方金和尖晶石逆结构。高分辨率透射电镜分析表明，尺寸为14 nm的Fe3O4颗粒与18 nm的Au颗粒相连。在Hela细胞上使用XTT法评估纳米颗粒的细胞毒性，结果显示非常低(Fe3O4的细胞存活率为98-89%，Au@Fe3O4 NPs的细胞存活率为99-91%)。这表明金提高了磁性纳米颗粒的生物相容性，使其在生物医学上的应用成为可能

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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