Relationship between Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Hyperhomocysteinemia in Patients with Ischemic Stroke: A Proof-of-Concept Randomized Trial

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Acta Neurologica Scandinavica Pub Date : 2023-09-19 DOI:10.1155/2023/6642768

Bing Luo, Yun Wang, Minjie Sun, Mei Feng, Wei Zhu, Sufang Xu

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Abstract

Background. This study is aimed at investigating the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hyperhomocysteinemia (HHCY) in patients with ischemic stroke (IS). Methods. This study retrospectively analyzed the clinical data and laboratory results of 110 IS patients. According to the cut-off value of HCY = 15 μmol/L, the included patients were divided into the normal HCY (NHCY, n = 69) and the high HCY (HHCY, n = 41) groups. The relationship between NLR, PLR, and HCY between these groups was then compared. Results. NLR and PLR levels in IS patients with HHCY were significantly higher than those in IS patients without HHCY (P < 0.05). Correlation analysis showed that NLR and PLR were positively correlated with hs-CRP, RDW, N, L, and HCY (P < 0.05). NLR and PLR were the largest predictors of IS-related HHCY, followed by WBC, hs-CRP, RDW, VLDL, and TG. Additionally, NLR and PLR were independent risk factors for IS-related HHCY. Conclusions. NLR and PLR may be fast, cheap, and easy-to-analyze biomarkers for predicting IS-related HHCY.

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缺血性卒中患者中性粒细胞与淋巴细胞比率、血小板与淋巴细胞比率和高同型半胱氨酸血症之间的关系:一项概念验证随机试验

背景。本研究旨在探讨缺血性卒中(is)患者中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与高同型半胱氨酸血症(HHCY)的关系。方法。本研究回顾性分析了110例IS患者的临床资料和实验室结果。根据HCY = 15 μ mol / L的临界值将纳入的患者分为正常HCY组(NHCY, n = 69)和高HCY组(HHCY, n = 41)。比较两组间NLR、PLR和HCY的关系。结果。合并HHCY的IS患者NLR和PLR水平显著高于未合并HHCY的IS患者(P <0.05)。相关分析显示NLR、PLR与hs-CRP、RDW、N、L、HCY呈正相关(P <0.05)。NLR和PLR是is相关HHCY的最大预测因子，其次是WBC、hs-CRP、RDW、VLDL和TG。此外，NLR和PLR是is相关HHCY的独立危险因素。结论。NLR和PLR可能是预测is相关HHCY的快速、廉价和易于分析的生物标志物。

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来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.