The Influence of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Platelet Distribution Widthon Myometrial Invasion in Endometrial Carcinoma: A Retrospective Study

Abstract

Objective: To estimate the stage of endometrial carcinoma, an easily reproducible and simple marker is needed. We aimed to find out whether the neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio, platelet distribution width (PDW) values have an impact on the degree of myometrial invasion in endometrial carcinoma. Material and Methods: The study was planned as a retrospective cross-sectional study between 2007 and 2014 in Ankara, Türkiye. After reviewing the patients' pathology reports, a total of 88 patients with adenocarcinoma of the endometrium were included in the study. Results: The age of the 88 women included in the study ranged from 44 to 92 years, with a mean age of 56.00 (inter quantile range=16.0) years. The ROC analysis showed that only the PDW and NLR values could statistically significantly differentiate between patients with less than half the depth of invasion and patients with more than half the depth of invasion (p=0.025, p=0.003). Accordingly, the significance of the PDW was 64.5% (95% confidence interval: 51.6-77.4); when the PDW value is less than 15.05, it predicts that the depth of invasion is more than half with 67.7% sensitivity and 61.4% selectivity. Conclusion: We found that preoperative PDW and NLR values can predict myometrial invasion in endometrial cancer.