Damage-Induced Softening of the Sclera: A Pseudo-Elastic Modeling Approach

Jose Colmenarez, Yingnan Zhai, Valentina Ochoa Mendoza, Pengfei Dong, Kenia Nunes, Donny Won Suh, Linxia Gu
{"title":"Damage-Induced Softening of the Sclera: A Pseudo-Elastic Modeling Approach","authors":"Jose Colmenarez, Yingnan Zhai, Valentina Ochoa Mendoza, Pengfei Dong, Kenia Nunes, Donny Won Suh, Linxia Gu","doi":"10.1115/1.4063467","DOIUrl":null,"url":null,"abstract":"Abstract The biomechanical properties of the sclera such as the stiffness, anisotropic behavior, and nonlinear stress–strain relationship have been extensively investigated for the pathogenesis study of ocular diseases. Even so, scarce mechanical investigations have been conducted on the damage in the sclera when subjected to large and repetitive deformations. Hence, the aim of this study is to quantify microstructural damage of the posterior and anterior sclera, through mechanical testing and model fitting. We performed uniaxial mechanical tests on scleral strips dissected from African green monkeys. Samples were subjected to strain-driven cycles of 5%, 10%, 15%, and 20% to evaluate the damage behavior commonly known as the Mullins effect. Experimental results showed qualitative changes in the stress–stretch curves when higher loading cycles were applied. A pseudo-elastic model accurately captured the curve trends across all tested samples, as indicated by a coefficient of determination above 0.96 and a subsequent finite element analysis (FEA) validation. Damage evolution and resultant permanent set demonstrated that considerable microstructural failure was attainable even at small strain levels and that the inherent plasticity had a similar contribution to stress-softening as the Mullins effect. Computed material and damage properties are expected to provide a broader understanding of the underlying mechanisms of ocular diseases and the development of more effective approaches for their treatment.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of engineering and science in medical diagnostics and therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1115/1.4063467","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract The biomechanical properties of the sclera such as the stiffness, anisotropic behavior, and nonlinear stress–strain relationship have been extensively investigated for the pathogenesis study of ocular diseases. Even so, scarce mechanical investigations have been conducted on the damage in the sclera when subjected to large and repetitive deformations. Hence, the aim of this study is to quantify microstructural damage of the posterior and anterior sclera, through mechanical testing and model fitting. We performed uniaxial mechanical tests on scleral strips dissected from African green monkeys. Samples were subjected to strain-driven cycles of 5%, 10%, 15%, and 20% to evaluate the damage behavior commonly known as the Mullins effect. Experimental results showed qualitative changes in the stress–stretch curves when higher loading cycles were applied. A pseudo-elastic model accurately captured the curve trends across all tested samples, as indicated by a coefficient of determination above 0.96 and a subsequent finite element analysis (FEA) validation. Damage evolution and resultant permanent set demonstrated that considerable microstructural failure was attainable even at small strain levels and that the inherent plasticity had a similar contribution to stress-softening as the Mullins effect. Computed material and damage properties are expected to provide a broader understanding of the underlying mechanisms of ocular diseases and the development of more effective approaches for their treatment.
损伤诱导的巩膜软化:一种伪弹性建模方法
巩膜的刚度、各向异性行为和非线性应力-应变关系等生物力学特性在眼部疾病的发病机制研究中得到了广泛的研究。尽管如此,在巩膜遭受大而重复的变形时,对其损伤的机械研究仍然很少。因此,本研究的目的是通过力学测试和模型拟合来量化后巩膜和前巩膜的微结构损伤。我们对非洲绿猴的巩膜条进行了单轴力学试验。试样分别承受5%、10%、15%和20%的应变驱动循环,以评估通常称为Mullins效应的损伤行为。实验结果表明,在较高的加载周期下,应力-拉伸曲线发生了质的变化。伪弹性模型准确地捕获了所有测试样品的曲线趋势,其决定系数高于0.96,随后进行了有限元分析(FEA)验证。损伤演化和由此产生的永久集表明,即使在小应变水平下,也可以实现相当大的微观结构破坏,并且固有塑性对应力软化的贡献与穆林斯效应相似。通过计算材料和损伤特性,可以更广泛地了解眼部疾病的潜在机制,并开发出更有效的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信