Sepsis Risk Factors in Neonatal Intensive Care Units of Public Hospitals in Southeast Ethiopia, 2020: A Retrospective Unmatched Case-Control Study

IF 1.3 Q3 PEDIATRICS
Gemechu Ganfure, Bikila Lencha
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引用次数: 0

Abstract

Background. Neonatal sepsis is a significant contributor to neonatal morbidity and mortality worldwide. It is more prevalent in developing countries. Thus, understanding the risk factors for neonatal sepsis is critical to minimizing the incidence of infection, particularly in Ethiopia. The purpose of this study was to identify the risk factors for neonatal sepsis in neonates admitted to neonatal intensive care units of public hospitals in Southeast Ethiopia in 2020. Method. An institution-based, retrospective unmatched case-control study was conducted on 97 cases and 194 controls in neonatal intensive care units of public hospitals in Southeast Ethiopia. A pretested, structured questionnaire was used to collect the data. Data was entered using EpiData 3.1 and analyzed using SPSS version 23. Bivariable and multivariable logistic regression analyses were performed to identify associated factors. An adjusted odds ratio with a 95% confidence interval was used to determine the degree of association, and statistical significance was declared at a p value of < 0.05. Results. In this study, 97 cases and 194 controls were included. About two-thirds (63.9%) of cases were with early onset neonatal sepsis (<7 days). Mode of delivery with spontaneous vaginal delivery (AOR:5.032; 95% CI (1.887-13.418)), type of birth attendant (traditional birth attendant) (AOR: 4.407 95% CI (1.213,16.004)), history of STI/UTI (AOR:2.543; 95% CI (1.313,4.925)), intrapartum fever (AOR:4.379; 95% CI (2.170,8.835)), APGAR score at the 5th minute < 7 (AOR:4.832; 95% CI (1.862,12.537)), neonate received resuscitation (AOR:3.830; 95% CI (1.753,8.369)), low birth weight (AOR:6.101; 95% CI (2.124,17.525)) were the identified risk factors for neonatal sepsis. Conclusion. Both maternal and neonatal factors contribute to the risk of neonatal sepsis. Spontaneous vaginal delivery, birth attended by the traditional birth attendant, history of STI/UTI, presence of intrapartum fever, low APGAR score at the 5th minute, neonate receiving resuscitation, and low birth weight were identified as independent risk factors for neonatal sepsis. Prompt identification of the aforementioned factors and management should be sought for all newborns.
2020年埃塞俄比亚东南部公立医院新生儿重症监护病房脓毒症危险因素:一项回顾性非匹配病例对照研究
背景。新生儿败血症是全球新生儿发病率和死亡率的重要因素。它在发展中国家更为普遍。因此,了解新生儿败血症的危险因素对于减少感染发生率至关重要,特别是在埃塞俄比亚。本研究的目的是确定2020年埃塞俄比亚东南部公立医院新生儿重症监护病房收治的新生儿脓毒症的危险因素。方法。对埃塞俄比亚东南部公立医院新生儿重症监护病房的97例病例和194例对照进行了一项基于机构的回顾性非匹配病例对照研究。使用预先测试的结构化问卷来收集数据。使用EpiData 3.1录入数据,使用SPSS 23进行分析。进行双变量和多变量logistic回归分析以确定相关因素。采用95%置信区间的校正优势比来确定关联程度,p值为<0.05. 结果。本研究纳入97例病例和194例对照。约三分之二(63.9%)的病例为早发性新生儿脓毒症(7天)。分娩方式为阴道自然分娩(AOR:5.032;95% CI(1.887-13.418))、接生员类型(传统接生员)(AOR: 4.407 95% CI(1.213,16.004))、性传播感染/尿路感染史(AOR:2.543;95% CI(1.313,4.925)),产时发热(AOR:4.379;95% CI(2.170,8.835),第5分钟APGAR评分<7(优势比:4.832;95% CI(1.862,12.537)),新生儿接受复苏(AOR:3.830;95% CI(1.753,8.369)),低出生体重(AOR:6.101;95% CI(2.124,17.525)为新生儿脓毒症的危险因素。结论。产妇和新生儿因素都有助于新生儿败血症的风险。阴道自然分娩、传统接生员接生、性传播感染/尿路感染史、产时发热、第5分钟APGAR评分低、新生儿接受复苏、低出生体重是新生儿脓毒症的独立危险因素。所有新生儿均应及时发现上述因素并进行处理。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
审稿时长
4 weeks
期刊介绍: International Journal of Pediatrics is a peer-reviewed, open access journal that publishes original researcharticles, review articles, and clinical studies in all areas of pediatric research. The journal accepts submissions presented as an original article, short communication, case report, review article, systematic review, or letter to the editor.
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